AI Article Synopsis
- Exopolysaccharides (EPSs) from a strain identified as Z171, isolated from Chinese sauerkraut, have potential as prebiotics due to their physiological benefits.
- The study examined the digestion and fecal fermentation of purified EPS (F-EPS1A), noting that it maintained its structural integrity through gastrointestinal processing.
- The results indicated that F-EPS1A altered gut microbiota composition, enhancing beneficial bacteria and increasing levels of short-chain fatty acids, suggesting it could be a valuable prebiotic for gut health.
Article Abstract
Exopolysaccharides (EPSs) produced by have important physiological activities and are commonly used as novel prebiotics. A strain of with high EPS yield was identified as ( Z171), which was isolated from Chinese sauerkraut. The objective of this study was to investigate the simulated digestion and fecal fermentation behavior of the purified exopolysaccharide fraction F-EPS1A from Z171 and its influence on the human intestinal flora composition. The digestion results showed that the primary structural characteristics of F-EPS1A, such as morphology, molecular weight, and monosaccharide composition remained stable after saliva and gastrointestinal digestion. Compared with the blank group, the fermentation of F-SPS1A by fecal microbiota decreased the diversity of the bacterial communities, significantly promoted the relative abundance of and , and decreased the relative abundance of , , and . Reverse transcription polymerase chain reaction (RT-PCR) analysis also showed that the population of markedly increased. Furthermore, the total short-chain fatty acid levels increased significantly, especially for butyric acid. Gas chromatography-mass spectrometry (GC-MS) results showed that F-EPS1A could be fermented by the human gut microbiota to synthesize organic acids and derivative metabolites that are beneficial to gut health. Therefore, these findings suggest that F-EPS1A could be exploited as a potential prebiotic.
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| http://dx.doi.org/10.1021/acs.jafc.4c02803 | DOI Listing |
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