AI Article Synopsis
- - Autoimmune gastritis (AIG) is an autoimmune disorder that destroys stomach cells, leading to intrinsic factor deficiency and reduced stomach acid production, which primarily affects the antral mucosa and can increase the risk of certain cancers.
- - The exact causes of AIG are not fully known, but it involves malfunctioning immune system responses that damage gastric tissue.
- - This review highlights the current understanding of inflammation in AIG and discusses potential new biomarkers and treatment targets to better address this medical issue.
Article Abstract
Autoimmune gastritis (AIG) is an autoimmune disorder characterized by the destruction of gastric parietal cells and atrophy of the oxyntic mucosa which induces intrinsic factor deficiency and hypo-achlorhydria. AIG predominantly affects the antral mucosa with AIG patients experiencing increased inflammation and a predisposition toward the development of gastric adenocarcinoma and type I neuroendocrine tumors. The exact pathogenesis of this autoimmune disorder is incompletely understood although dysregulated immunological mechanisms appear to major contributors. This review of autoimmune gastritis, an unmet medical need, summarizes current knowledge on pro- and anti-inflammatory cytokines and strategies for the discovery of novel biomarkers and potential pharmacological targets.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11347309 | PMC |
| http://dx.doi.org/10.3389/fphar.2024.1450558 | DOI Listing |
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