AI Article Synopsis

  • Scientists have created a new special imaging agent called pafolacianine that helps doctors during surgery for certain cancers, like lung and ovarian cancers.
  • They tested it on young adults with serious conditions and had success in finding and treating their tumors.
  • This new approach could make surgeries better by helping doctors see cancer spots much more clearly, which means they can remove more cancer safely.

Article Abstract

A new generation of disease-specific molecular imaging agents is poised to revolutionize fluorescence-guided surgery. Pafolacianine has been approved for adult lung and ovarian cancers. We demonstrate a proof of concept for pediatric surgeons treating young adults with pulmonary metastatic sarcomas. Five successful fluorescence-guided pulmonary metastasectomy operations were performed in young adult patients with metastatic osteosarcoma or Ewing sarcoma following administration of pafolacianine. All osteosarcoma lesions identified using standard techniques were also markedly fluorescent in patients. Novel fluorescent molecular agents targeted to tumor-specific receptors have promise of increased sensitivity and specificity for detecting metastatic nodules and enhancing surgical clearance of disease.

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Source
http://dx.doi.org/10.1002/pbc.31293DOI Listing

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