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A Systematic Review of Challenges and Opportunities in the Implementation of Managed Entry Agreements for Advanced Therapy Medicinal Products.
Clin Ther
December 2024
Department of Epidemiology & Health Economics, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands. Electronic address:
Purpose: Managed Entry Agreements (MEAs) are agreements between firms and competent authorities for pricing and reimbursement, designed to enable coverage of new medicines while managing uncertainties around their financial impact or performance. Although these agreements can facilitate patient access, their complexity and costs seem to dampen enthusiasm for implementation. Nevertheless, MEAs remain a potential route, particularly for high-cost drugs with uncertain value claims.
View Article and Find Full Text PDFIs Private Education Worth it? Evidence from School-to-Work Transitions in Chile.
Labour Econ
October 2024
Department of Economics, University of Maryland and NBER.
Using comprehensive longitudinal data from Chile, we examine the impact of attending a private high school on labor market outcomes. The empirical strategy exploits conditional independence assumptions and leverages the effects of self-selection based on ability. We establish that private high schools boost average adult earnings by 99-144 dollars a month (relative to public schools), equivalent to a 15-22% premium.
View Article and Find Full Text PDFPrivate Equity Ownership of US Opioid Treatment Programs.
JAMA Psychiatry
December 2024
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
The overlooked burden of persistent physical symptoms: a call for action in European healthcare.
Lancet Reg Health Eur
January 2025
Department of Psychosomatic Medicine and Psychotherapy, Centre for Internal Medicine, University Medical Centre Hamburg-Eppendorf, Martinistraße 52, Hamburg 20246, Germany.
Regardless of their cause, persistent physical symptoms are distressing somatic complaints that occur on most days for at least several months. They are common in patients with somatic diseases, functional somatic disorders, mental disorders, and undiagnosed medical conditions and are often associated with significant impairment and medical costs. Despite their prevalence and impact, persistent physical symptoms are often overlooked in medical care.
View Article and Find Full Text PDFEnhancing security in financial transactions: a novel blockchain-based federated learning framework for detecting counterfeit data in fintech.
PeerJ Comput Sci
September 2024
College of Engineering, Karachi Institute of Economics and Technology, Karachi, Sindh, Pakistan.
Fintech is an industry that uses technology to enhance and automate financial services. Fintech firms use software, mobile apps, and digital technologies to provide financial services that are faster, more efficient, and more accessible than those provided by traditional banks and financial institutions. Fintech companies take care of processes such as lending, payment processing, personal finance, and insurance, among other financial services.
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