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Immunoinformatics design of a novel multiepitope vaccine candidate against non-typhoidal salmonellosis caused by Salmonella Kentucky using outer membrane proteins A, C, and F.
PLoS One
January 2025
Foot and Mouth Disease Department, National Veterinary Research Institute, Vom, Plateau State, Nigeria.
The global public health risk posed by Salmonella Kentucky (S. Kentucky) is rising, particularly due to the dissemination of antimicrobial resistance genes in human and animal populations. This serovar, widespread in Africa, has emerged as a notable cause of non-typhoidal gastroenteritis in humans.
View Article and Find Full Text PDFCD3+ Tumor-Infiltrating Lymphocytes in Breast Carcinoma: Their Prognostic Role and Association With Clinical Parameters.
Cureus
December 2024
Pathology, BLDE (Deemed to be University) Shri B M Patil Medical College, Hospital and Research Centre, Vijayapura, IND.
Background Breast carcinoma cases are rising steadily and represent a major cause of mortality and morbidity in India. In response to breast carcinoma, the immune system is activated, resulting in lymphocyte infiltration in and around the tumor nests. This interaction between the tumor and immune system is the basis for studying tumor-infiltrating lymphocytes (TILs).
View Article and Find Full Text PDFFunctional and Structural Investigation of Myenteric Neurons in the Human Colon.
Gastro Hep Adv
August 2024
Institute for Physiology and Cell Biology, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Background And Aims: The enteric nervous system independently controls gastrointestinal function including motility, which is primarily mediated by the myenteric plexus, therefore also playing a crucial role in functional intestinal disorders. Live recordings from human myenteric neurons proved to be challenging due to technical difficulties. Using the neuroimaging technique, we are able to record human colonic myenteric neuronal activity and investigate their functional properties in a large cohort of patients.
View Article and Find Full Text PDFEscherichia coli growing under antimicrobial gallium nitrate stress reveals new processes of tolerance and toxicity.
Sci Rep
January 2025
Department of Biological Sciences, University of Calgary, Calgary, AB, T2N 1N4, Canada.
Metals have been used throughout history to manage disease. With the rising incidence of antibiotic-resistant bacterial strains, metal-based antimicrobials (MBAs) have re-emerged as an alternative to combat infections. Gallium nitrate has shown promising efficacy against several pathogens.
View Article and Find Full Text PDFComprehensive Analysis of Factors Influencing Patients' Preferences and Attitudes toward Dental Treatment Choices.
Ann Afr Med
December 2024
Department of Public Health Dentistry, Government Dental College, Kottayam, Kerala, India.
Introduction: In recent years, patient preferences and attitudes have become crucial in shaping dental treatment choices and service utilization. Understanding these preferences is crucial for improving service delivery and patient satisfaction.
Aim: This study aims to comprehensively analyze the factors influencing these preferences, focusing on demographic, socio-economic, and behavioral variables, and the growing role of social media in healthcare decisions.
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