1573-25092722024OctSchizophr ResDisturbance at the self-other boundary in schizophrenia: Linking phenomenology to clinical neuroscience.516051-6010.1016/j.schres.2024.07.048S0920-9964(24)00355-4In this selective review, we describe the current neuroscientific literature on disturbances of the self-other boundary in schizophrenia as they relate to structural and experiential aspects of the self. Within these two broad categories, the structural self includes body ownership and agency, and the experiential self includes self-reflection, source monitoring, and self-referential and autobiographical memory. Further, we consider how disturbances in these domains link to the phenomenology of schizophrenia. We identify faulty internal predictive coding as a potential mechanism of disturbance in body ownership and agency, which results in susceptibility to bias (over- or under-attributing outcomes to one's own actions or intentions). This is reflected in reduced activity in the temporoparietal junction (TPJ), a heteromodal association area implicated in several aspects of self-other processing, as well as reduced fronto-parietal functional connectivity. Deficits of the experiential self in schizophrenia may stem from a lack of salience of self-related information, whereby the mental representation of self is not as rich as in healthy controls and therefore does not result in the same level of privileged processing. As a result, memory for self-referential material and autobiographical memory processes is impaired, which hinders creation of a cohesive life narrative. Impairments of the experiential self implicate abnormal activation patterns along the cortical midline, including medial prefrontal cortex and posterior cingulate/precuneus, as well as TPJ. In fact, TPJ appears to be involved in all the reviewed aspects of the self-other disturbance. We conclude with suggestions for future work, including implications for interventions with critical timing considerations.Published by Elsevier B.V.JimenezAmy MAMDepartment of Veterans Affairs, Desert Pacific Mental Illness Research, Education, and Clinical Center, USA; VA Rehabilitation R&D Center on Enhancing Community Integration for Homeless Veterans, USA; Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, UCLA, USA. Electronic address: amjimenez@ucla.edu.GreenMichael FMFDepartment of Veterans Affairs, Desert Pacific Mental Illness Research, Education, and Clinical Center, USA; VA Rehabilitation R&D Center on Enhancing Community Integration for Homeless Veterans, USA; Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, UCLA, USA.engJournal ArticleReview20240826