The developments of C-N bond formation electrochemical Ritter-type reactions.

Org Biomol Chem

School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.

Published: September 2024

With the development of organic electrochemical synthesis, a series of notable achievements have been made in electrochemical Ritter amination reactions, which have enriched the methods available for constructing C-N bonds. In this review, electrochemical Ritter amination reactions are introduced based on the classification of reaction substrates, including olefins, aromatics, alkylbenzenes, and the less reported carboxylic acids, ketones, sulfides, and alkanes. The application of electrochemical technology to Ritter reactions has improved the harsh conditions of the traditional reactions, and extended the substrate scope and the structural diversity of the products. The application value of Ritter reactions in organic synthesis has also been further expanded.

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Source
http://dx.doi.org/10.1039/d4ob01210kDOI Listing

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