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Background: Healthcare systems need to address the high healthcare use of frail older adults. The Geriatric Services Hub (GSH) is a novel program in Singapore that delivers frailty screening, comprehensive geriatric assessment and coordinated care for community-dwelling older persons with bio-psycho-social needs. We aimed to evaluate the effects of the GSH on healthcare use.
View Article and Find Full Text PDFLegacy and emerging organophosphate flame retardants (OPFRs) in water and sediment from the Pearl River Delta to the adjacent coastal waters of the South China Sea: Spatioseasonal variations, flux estimation and ecological risk.
Environ Pollut
January 2025
Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address:
The industrialization and urbanization along the Pearl River Delta (PRD) have exacerbated the issue of pollution in aquatic environments by organophosphate flame retardants (OPFRs). Historical cumulative pollution from legacy OPFRs, combined with newly emerging OPFRs, has increased the severity and complexity of OPFR pollution in this region. We explored the contamination profile, input flux and risk of legacy and emerging OPFRs in surface waters and in sediment samples of the PRD.
View Article and Find Full Text PDFSnakebites, a neglected public health concern: an analysis of distribution, trends and incidence of snakebite cases reported to health facilities in the Volta Region of Ghana, 2018-2023.
Trans R Soc Trop Med Hyg
January 2025
Volta Regional Health Directorate, Ghana Health Service, Ho, Box 72, Ghana.
Background: Snakebite affects 5.4 million people annually, causing up to 2.7 million envenoming cases and 137 880 deaths.
View Article and Find Full Text PDFOptimization and Calibration of 384-well Kinetic Ca Mobilization Assays for the Human Transient Receptor Potential Cation Channels TRPM8, TRPV1, and TRPA1.
SLAS Discov
December 2024
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA; University of Pittsburgh Hillman Cancer Center, Pittsburgh, PA 15232, USA. Electronic address:
Development, optimization, and calibration of human transient receptor potential (TRP) channel Ca mobilization assays for TRPM8, TRPV1, and TRPA1 are described. Heterologous expression of hTRPM8 in HEK293T cells was required for anti-TRPM8 antibody staining and TRPM8 agonist induced Ca mobilization signals which were both used to optimize transfection efficiency. FLIPR Calcium 6 dye concentration, loading time, and TRPM8 transfected cell seeding density were optimized and a DMSO tolerance of ≤0.
View Article and Find Full Text PDFConformationally Adaptable Extractant Flexes Strong Lanthanide Reverse-Size Selectivity.
J Am Chem Soc
January 2025
Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Chemical selectivity is traditionally understood in the context of rigid molecular scaffolds with precisely defined local coordination and chemical environments that ultimately facilitate a given transformation of interest. By contrast, nature leverages dynamic structures and strong coupling to enable specific interactions with target species in otherwise complex media. Taking inspiration from nature, we demonstrate unconventional selectivity in the solvent extraction of light over heavy lanthanides using a conformationally flexible ligand called octadecyl acyclopa (ODA).
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