AI Article Synopsis

  • - Reports have indicated potential cardiovascular issues, particularly thrombosis, linked to mRNA vaccines for COVID-19, raising concerns about their safety.
  • - A study of 184 hospital staff showed a significant increase in anti-phosphatidylethanolamine antibodies after vaccination, which are often associated with pregnancy complications.
  • - Despite these findings, there were no notable changes in other antibody levels, and the relationship between vaccination and health risks like thrombosis or pregnancy loss is still unclear, indicating a need for further research.

Article Abstract

Multiple concerning reports have emerged of cardiovascular complications, particularly thrombosis, following mRNA vaccination against the SARS-CoV-2 pathogen. The presence of serologically persistent anti-phospholipid antibodies is a characteristic of antiphospholipid syndrome, which presents with clinical manifestations including thrombosis or pregnancy morbidity. Anti-SARS-CoV-2 mRNA vaccines pose a theoretical risk of cross-reactivity between the SARS-CoV-2 spike protein and phospholipids in host tissues. In this study, serum anti-phospholipid antibody titers before and after SARS-CoV-2 mRNA vaccination were compared among 184 hospital staff members. Although no significant differences were found in terms of antibody titers targeting cardiolipin and β2-glycoprotein I, post-vaccination antibody titers targeting phosphatidylethanolamine were found to be significantly increased compared to pre-vaccination levels ( = 0.008). Anti-phosphatidylethanolamine antibodies are the most common anti-phospholipid antibodies detected in patients with recurrent miscarriages at < 10 weeks of gestation. However, the association between vaccination and these types of adverse events remains unknown, thus warranting further investigation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345390PMC
http://dx.doi.org/10.1016/j.jvacx.2024.100539DOI Listing

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