AI Article Synopsis
- The relationship between propionyl-CoA metabolism and gene expression regulation in the heart is not well understood.
- Recent research has uncovered how abnormal propionyl-CoA oxidation affects chromatin acylation and gene transcription.
- These findings are particularly observed in mouse models with heart dysfunction caused by propionic acidemia.
Article Abstract
The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346590 | PMC |
| http://dx.doi.org/10.1038/s44161-023-00381-0 | DOI Listing |
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