AI Article Synopsis
- Erythropoietin-producing hepatoma (Eph) receptors are a major family of receptor tyrosine kinases that influence key biological processes and are involved in cancer progression.
- These receptors interact with ephrins to regulate essential functions like embryo development, tissue formation, and tumor cell survival.
- Recent studies have shown their significant role in cardiovascular health, affecting conditions such as atherosclerosis and cardiac fibrosis, highlighting their potential for new treatments in heart-related diseases.
Article Abstract
Erythropoietin-producing hepatoma (Eph) receptors, comprising the largest family of receptor tyrosine kinases (RTKs), exert profound influence on diverse biological processes and pathological conditions such as cancer. Interacting with their corresponding ligands, erythropoietin-producing hepatoma receptor interacting proteins (Ephrins), Eph receptors regulate crucial events like embryonic development, tissue boundary formation, and tumor cell survival. In addition to their well-established roles in embryonic development and cancers, emerging evidence highlights the pivotal contribution of the Ephrin/Eph family to cardiovascular physiology and pathology. Studies have elucidated their involvement in cardiovascular development, atherosclerosis, postnatal angiogenesis, and, more recently, cardiac fibrosis and calcification, suggesting a promising avenue for therapeutic interventions in cardiovascular diseases. There remains a need for a comprehensive synthesis of their collective impact in the cardiovascular context. By exploring the intricate interactions between Eph receptors, ephrins, and cardiovascular system, this review aims to provide a holistic understanding of their roles and therapeutic potential in cardiovascular health and diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345580 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.110556 | DOI Listing |
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