AI Article Synopsis
- Gastrointestinal cancer is a prevalent type of cancer that is the subject of extensive research to uncover its causes and explore new treatments.
- Obesity, particularly morbid obesity, is linked to worse cancer outcomes due to its impact on tumor behavior and the surrounding environment, highlighting the complex physiological changes it causes.
- Adipose tissue is now recognized as an active endocrine organ that releases growth factors and adipokines, which may influence cancer progression through pathways involving insulin, IGF-1, and sex hormones.
Article Abstract
Gastrointestinal cancer represents one of the most encountered oncologic pathologies and research studies are performed thoroughly in order to identify the exact causes and possible novel therapies. Obesity is a complex manifestation associated with numerous physiological and primarily molecular changes capable of tackling the behavior of tumoral cells and the nearby or faraway microenvironment. Adipose tissue has been once considered to have limited physiological roles, but in recent years it has been recognized as an active endocrine organ, secreting substances such as growth factors and adipokines. From an epidemiological perspective, obesity - particularly morbid obesity - is linked to an unfavorable progression of cancer. A key mechanism that may elucidate the association between obesity and cancer involves the insulin and insulin-like growth factor (IGF-1) pathway, sex hormones, and adipokines.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345048 | PMC |
| http://dx.doi.org/10.26574/maedica.2024.19.2.360 | DOI Listing |
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