AI Article Synopsis
- The fruit fly serves as a crucial model organism in biological research, particularly in understanding developmental processes at the molecular level.
- Significant advancements have been accomplished in the last two decades regarding the molecular mechanisms that control hematopoiesis, the formation of blood cells.
- This review focuses on how the hematopoietic organ in fruit fly larvae has provided insights into the interactions between signaling pathways and transcription factors that govern the maintenance and differentiation of progenitor cells.
Article Abstract
As a model organism, the fruit fly () has assumed a leading position in modern biological research. The genetic system has a number of advantages making it a key model in investigating the molecular mechanisms of metazoan developmental processes. Over the past two decades, significant progress has been made in understanding the molecular mechanisms regulating hematopoiesis. This review discusses the major advances in investigating the molecular mechanisms involved in maintaining the population of multipotent progenitor cells and their differentiation into mature hemocytes in the hematopoietic organ of the larva. The use of the hematopoietic organ as a model system for hematopoiesis has allowed to characterize the complex interactions between signaling pathways and transcription factors in regulating the maintenance and differentiation of progenitor cells through the signals from the hematopoietic niche, autocrine and paracrine signals, and the signals emanated by differentiated cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345091 | PMC |
| http://dx.doi.org/10.32607/actanaturae.27410 | DOI Listing |
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