AI Article Synopsis
- Traumatic brain injury (TBI) causes significant breakdown of membrane lipids, and a study was conducted to analyze the lipid profile in plasma for patients with varying degrees of TBI compared to controls.
- Key lipid changes, including decreases in specific lipids like docosahexaenoic acid (DHA) and lysophosphatidylcholine (LPC), were observed at 24 and 72 hours post-injury, helping to distinguish TBI patients from controls.
- Increased levels of neurofilament light (NFL) and certain cytokines (like IL-6) were associated with more severe injuries, indicating potential correlations between lipid changes, neuronal injury, and inflammation in TBI cases.
Article Abstract
Traumatic brain injury (TBI) leads to major membrane lipid breakdown. We investigated plasma lipids over 3 days post-TBI, to identify a signature of acute human TBI and assess its correlation with neuronal injury and inflammation. Plasma from patients with TBI (Abbreviated Injury Scale (AIS)3 - serious injury, n = 5; AIS4 - severe injury, n = 8), and controls (n = 13) was analysed for lipidomic profile, neurofilament light (NFL) and cytokines, and the omega-3 index was measured in red blood cells. A lipid signature separated TBI from controls, at 24 and 72 h. Major species driving the separation were: lysophosphatidylcholine (LPC), phosphatidylcholine (PC) and hexosylceramide (HexCer). Docosahexaenoic acid (DHA, 22:6) and LPC (0:0/22:6) decreased post-injury. NFL levels were increased at 24 and 72 h post-injury in AIS4 TBI vs. controls. Interleukin (IL-)6, IL-2 and IL-13 were elevated at 24 h in AIS4 patients vs. controls. NFL and IL-6 were negatively correlated with several lipids. The omega-3 index at admission was low in all patients (controls: 4.3 ± 1.1% and TBI: 4.0 ± 1.1%) and did not change significantly over 3 days post-injury. We have identified specific lipid changes, correlated with markers of injury and inflammation in acute TBI. These observations could inform future lipid-based therapeutic approaches.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572080 | PMC |
| http://dx.doi.org/10.1177/0271678X241276951 | DOI Listing |
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