AI Article Synopsis
- The study of aging has traditionally focused on specific hallmarks that influence health as we age, but there's a growing understanding of how these hallmarks interact with each other.
- A key challenge in aging research is personalizing aging experiences based on individual genetic and environmental factors.
- This editorial emphasizes the importance of considering mitochondrial dysfunction as a hallmark of aging, using it as a case study to showcase how acknowledging variability can lead to new insights in personalized aging strategies.
Article Abstract
The hallmarks of aging have been influential in guiding the biology of aging research, with more recent and growing recognition of the interdependence of these hallmarks on age-related health outcomes. However, a current challenge is personalizing aging trajectories to promote healthy aging, given the diversity of genotypes and lived experience. We suggest that incorporating heterogeneity-including intrinsic (e.g., genetic and structural) and extrinsic (e.g., environmental and exposome) factors and their interdependence of hallmarks-may move the dial. This editorial perspective will focus on one hallmark, namely mitochondrial dysfunction, to exemplify how consideration of heterogeneity and interdependence or crosstalk may reveal new perspectives and opportunities for personalizing aging research. To this end, we highlight heterogeneity within mitochondria as a model.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464123 | PMC |
| http://dx.doi.org/10.1111/acel.14296 | DOI Listing |
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