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| http://dx.doi.org/10.1186/s12889-024-19845-4 | DOI Listing |
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Electroencephalographic (EEG) recordings in individuals with Fragile X Syndrome (FXS) and the mouse model of FXS ( KO) display cortical hyperexcitability at rest, as well as deficits in sensory-driven cortical network synchrony. A form of circuit hyperexcitability is observed in cortical slices of KO mice as prolonged persistent activity, or Up, states. It is unknown if the circuit mechanisms that cause prolonged Up states contribute to FXS-relevant EEG phenotypes.
View Article and Find Full Text PDFWernicke Encephalopathy Presenting With Syndrome of Inappropriate Antidiuretic Hormone.
Pediatr Neurol
December 2024
University of Alabama, Birmingham, Children's of Alabama, Birmingham, Alabama.
Wernicke encephalopathy is a well-described neurological complication of thiamine deficiency that is classically characterized by a triad of mental confusion, ophthalmoplegia, and gait ataxia. Although most commonly linked to alcoholism and thiamine deficiency in adults, it can present in pediatric patients. Wernicke encephalopathy presenting as dysnatremias is not well described.
View Article and Find Full Text PDFA shared serial order system for verbal working memory and language production: evidence from aphasia.
Cogn Neuropsychol
January 2025
Department of Psychological Sciences, Rice University, Houston, Texas, USA.
Many aspects of human performance require producing sequences of items in serial order. The current study takes a multiple-case approach to investigate whether the system responsible for serial order is shared across cognitive domains, focusing on working memory (WM) and word production. Serial order performance in three individuals with post-stroke language and verbal WM disorders (hereafter persons with aphasia, PWAs) were assessed using recognition and recall tasks for verbal and visuospatial WM, as well as error analyses in spoken and written production tasks to assess whether there was a tendency to produce the correct phonemes/letters in the wrong order.
View Article and Find Full Text PDFMetabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia-reperfusion injury via Wnt/β-catenin pathway modulation.
Nat Prod Bioprospect
January 2025
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Anchusa italica Retz. (AIR), a traditional herbal remedy, is commonly applied in managing heart and brain disorders. However, its specific function and mechanism in acute cerebral ischemia-reperfusion injury (CIRI) are not fully understood.
View Article and Find Full Text PDFFixation Stability Deficits in Anisometropic Amblyopia.
Invest Ophthalmol Vis Sci
January 2025
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou, China.
Purpose: The purpose of this study was to investigate the relationship between fixation stability deficits in anisometropic amblyopia and various visual functions, as well as the underlying retinal structure.
Methods: All 164 patients with anisometropic amblyopia were recruited in this cross-sectional study. The contrast sensitivity function (CSF) was measured using the qCSF method, whereas the MP-3 microperimeter was used to assess fixation stability and locate the preferred retinal locus.
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