AI Article Synopsis
- This study examined the link between vitamin D levels and liver disease markers in two patient groups: a control group (CG) and a study group (SG).
- The results showed significant differences in vitamin D levels between the groups, with SG displaying variations based on vitamin D status and a correlation with liver-related markers, suggesting a connection to non-alcoholic fatty liver disease (NAFLD).
- The findings indicate a complex relationship where lower vitamin D levels are associated with higher markers of liver disease in the SG, prompting the need for further research to understand this relationship and its potential clinical relevance.
Article Abstract
Background/aim: This study investigated the correlation between vitamin D levels and serological markers of liver diseases in two groups of patients: the control group (CG) and the study group (SG).
Materials And Methods: The study analyzed data on vitamin D levels categorized as insufficient, sufficient, and optimal, along with serological markers, such as alpha2-macroglobulin, haptoglobin, apolipoprotein A1, bilirubin total, gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose, total cholesterol, and triglycerides.
Results: The results indicate significant differences in vitamin D levels between the two groups, particularly in SG, where vitamin D levels varied according to its status and correlated with serological markers. Marker levels, including alpha2-macroglobulin, glucose, and total cholesterol, were notably higher in SG compared to CG, suggesting a potential association with non-alcoholic fatty liver disease (NAFLD). Further analysis using Pearson correlation revealed a strong, inverse relationship between vitamin D levels and FibroTest, NashTest, alpha2-globulin, and glucose. Additionally, increasing FibroTest and NashTest stages, as well as levels of alpha2-macroglobulin and glucose, were associated with lower vitamin D levels in SG.
Conclusion: These findings under-score the complex interplay between vitamin D and serological markers in NAFLD, highlighting the potential significance of vitamin D levels in disease progression. Further research is warranted to elucidate the mechanisms underlying this relationship and its clinical implications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363789 | PMC |
| http://dx.doi.org/10.21873/invivo.13692 | DOI Listing |
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