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The Role of Immune Semaphorins in Sepsis-A Prospective Cohort Study.
Microorganisms
December 2024
Department for Infectious Diseases, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
In sepsis, a balanced pro-inflammatory and anti-inflammatory response results in the bacterial clearance and resolution of inflammation, promoting clinical recovery and survival. Semaphorins, a large family of secreted and membrane-bound glycoproteins, are newly recognized biomarkers and therapeutic targets in immunological and neoplastic disorders. Although semaphorins might also be a crucial part of host defense responses to infection, their role in sepsis is yet to be determined.
View Article and Find Full Text PDFSemaphorins and its receptors: Emerging cellular biomarkers and therapeutic targets in autoimmune and inflammatory disorders.
Life Sci
January 2025
Infectious Diseases & Immunology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India. Electronic address:
Semaphorins have been discovered to play an array of roles in immune regulation, especially in the complex field of inflammatory and autoimmune disorders. Originally discovered for their critical role in directing axon growth during brain development, semaphores have since been shown to have versatile actions. They are distinguished by a conserved extracellular sema domain with a 7-blade beta propeller structure.
View Article and Find Full Text PDFSEMA3A as a biomarker of primary ventricular fibrillation complicating STEMI.
Heart Rhythm
August 2024
Univ Lyon, CarMeN Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Groupement Hospitalier Est, Bron, France; Unité de Soins Intensifs Cardiologiques, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France.
A Study on Semaphorin 3A Level in Juvenile-onset Systemic Lupus Erythematosus Patients.
Curr Rheumatol Rev
July 2024
Pediatrics Department Misr University for Science and Technology, Cairo, Egypt.
Background: Juvenile-onset systemic lupus erythematosus (jSLE) is an uncommon yet severe autoimmune/inflammatory condition affecting multiple bodily systems, typically manifest-ing before the age of 18. This disease exhibits significant complexity, displaying considerable variation among patients. Its effects can range in severity from minor to fatal, characterized by a pattern of recurring flare-ups and periods of remission, making its natural progression difficult to predict.
View Article and Find Full Text PDFmiR-24-3p and miR-484 are potential biomarkers for neurodegeneration in multiple sclerosis.
Heliyon
June 2024
Neurology Clinic, Al-Amiri Hospital, Kuwait City, Kuwait.
Multiple sclerosis (MS) is a complex, neurodegenerative chronic disorder. Circulating diagnostic biomarkers for MS have remained elusive, and those proposed so far have limited sensitivity and specificity to MS. Plasma-circulating microRNAs (miRNAs) have advantageous biochemical and physiological attributes that can be utilized in clinical testing and disease monitoring.
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