AI Article Synopsis
- - Single-cell techniques have shown that tumors are made up of various genetically distinct cell subclones, each with different mutations and gene expressions, but the larger tumor environment has not been fully explored.
- - Recent advancements in spatial multi-omics technologies have started to uncover how cells interact within the tumor microenvironment and how the tumor affects and is affected by its host.
- - These spatial approaches not only enhance traditional cancer treatments like surgery and chemotherapy but also have the potential to advance new targeted therapies, especially in immunotherapy, leading to a review of their future prospects in cancer research.
Article Abstract
Single-cell techniques have convincingly demonstrated that tumor tissue usually contains multiple genetically defined cell subclones with different gene mutation sets as well as various transcriptional profiles, but the spatial heterogeneity of the microenvironment and the macrobiological characteristics of the tumor ecosystem have not been described. For the past few years, spatial multi-omics technologies have revealed the cellular interactions, microenvironment, and even systemic tumor-host interactions in the tumor ecosystem at the spatial level, which can not only improve classical therapies such as surgery, radiotherapy, and chemotherapy but also promote the development of emerging targeted therapies in immunotherapy. Here, we review some emerging spatial omics techniques in cancer research and therapeutic applications and propose prospects for their future development.
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| http://dx.doi.org/10.1177/03008916241271458 | DOI Listing |
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