Reactions to Vicryl have rarely been reported in the literature. Moreover, a reaction that begins less than 24 hours postoperatively is even rarer. We present a case of Vicryl hypersensitivity that developed within 24 hours at the site of the wounds following arthroscopic anterior cruciate ligament (ACL) reconstruction and meniscal repair. A 32-year-old male patient underwent arthroscopic ACL reconstruction and lateral meniscus repair due to an injury on the soccer field. On postoperative day one, erythema and edema were observed around the wounds, and the patient complained of itching and tenderness in the same areas. Despite local and systemic medication for infection, contact dermatitis, and antiseptic allergy, no improvement was noted. Vicryl hypersensitivity was suspected. Vicryl was removed, and a polydioxanone suture (PDS) was used instead, resulting in clinical improvement for the patient. In patients presenting with erythema, edema, blistering, itching, and tenderness around the wound, Vicryl hypersensitivity as a differential diagnosis can be considered after ruling out common causes. Hypersensitivity tests may be performed in suspected cases.
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http://dx.doi.org/10.7759/cureus.65255 | DOI Listing |
Molecules
August 2024
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641, Yamazaki, Noda 278-8510, Chiba, Japan.
Compared with oral or injection administration, percutaneous immunotherapy presents a promising treatment modality for food allergies, providing low invasiveness and safety. This study investigated the efficacy of percutaneous immunotherapy using hen egg lysozyme (HEL)-loaded PLGA-PEG-PLGA nanoparticles (NPs), as an antigen model protein derived from egg white, compared with that of HEL-loaded chitosan hydroxypropyltrimonium chloride (CS)-modified PLGA NPs used in previous research. The intradermal retention of HEL in excised mouse skin was measured using Franz cells, which revealed a 2.
View Article and Find Full Text PDFCureus
July 2024
Department of Orthopaedics and Traumatology, Baltalimani Metin Sabanci Bone Diseases Training and Research Hospital, Istanbul, TUR.
Reactions to Vicryl have rarely been reported in the literature. Moreover, a reaction that begins less than 24 hours postoperatively is even rarer. We present a case of Vicryl hypersensitivity that developed within 24 hours at the site of the wounds following arthroscopic anterior cruciate ligament (ACL) reconstruction and meniscal repair.
View Article and Find Full Text PDFNeurol Res
October 2024
Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
BMC Vet Res
November 2020
Center of Comparative Medicine (DC) and Diagnostic Pathology Laboratory (BS), Baylor College of Medicine, Houston, TX, 77030, USA.
Background: Polyglactin 910 is a synthetic braided, absorbable suture commonly used in surgery. Though polyglactin 910 suture-related pseudoinfection is well documented in the human literature, it has not been previously reported in the veterinary literature.
Case Description: A 3-year-old female, ovariectomized but otherwise experimentally naïve Yucatan pig was evaluated for a several week history of bilateral multifocal abscesses in the area of the paralumbar fossa, which continued to worsen despite oral antibiotics and non-steroidal anti-inflammatory medications.
Gastroenterology
May 2020
Department of Microbiology and Immunology, Northwestern University, Chicago, Illinois; Cour Pharmaceutical Development Company, Northbrook, Illinois; Discipline of Pathology, School of Medical Sciences, Bosch Institute, Sydney Medical School, University of Sydney, Sydney, Australia; Interdepartmental Immunobiology Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Background & Aims: Celiac disease could be treated, and potentially cured, by restoring T-cell tolerance to gliadin. We investigated the safety and efficacy of negatively charged 500-nm poly(lactide-co-glycolide) nanoparticles encapsulating gliadin protein (TIMP-GLIA) in 3 mouse models of celiac disease. Uptake of these nanoparticles by antigen-presenting cells was shown to induce immune tolerance in other animal models of autoimmune disease.
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