This case report highlights the rehabilitation outcomes of a 24-year-old female who received inadvertent intrathecal digoxin during a routine cesarean section, leading to encephalomeningitis, vestibulocochlear neuritis, and incomplete paraplegia. Despite initial neurological deficits, the patient demonstrated significant improvement in both cognition and functional mobility during a one-month inpatient rehabilitation program, ultimately achieving ambulation with assistive devices. This case underscores the potential for rehabilitation of neurological sequela following accidental intrathecal digoxin administration.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344593PMC
http://dx.doi.org/10.7759/cureus.65376DOI Listing

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This case report highlights the rehabilitation outcomes of a 24-year-old female who received inadvertent intrathecal digoxin during a routine cesarean section, leading to encephalomeningitis, vestibulocochlear neuritis, and incomplete paraplegia. Despite initial neurological deficits, the patient demonstrated significant improvement in both cognition and functional mobility during a one-month inpatient rehabilitation program, ultimately achieving ambulation with assistive devices. This case underscores the potential for rehabilitation of neurological sequela following accidental intrathecal digoxin administration.

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Digoxin is a Na-K ATPase inhibitor commonly used to treat heart failure and atrial fibrillation. It is only approved for oral or intravenous (IV) use. There is no approved indication for intrathecal administration.

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Inadvertent Intrathecal Administration of Digoxin, with Review of the Literature.

Case Rep Neurol Med

October 2023

Department of Intensive Care, Carson Tahoe Health, Carson City, NV, USA.

While the systemic effects of digoxin have been studied, limited data exist on the effects of neuraxial administration. Prior case reports document how digoxin and lidocaine share indistinguishable vials and were inadvertently stocked together in spinal and epidural anesthesia kits, necessitating a need for further implementation of safety measures. Here, we report the poor progression and brain death of a postpartum woman after accidental administration of intrathecal digoxin during a routine elective cesarean section (C-section).

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Cardiovascular Drug Administration Errors During Neuraxial Anesthesia or Analgesia-A Narrative Review.

J Cardiothorac Vasc Anesth

February 2023

Department of Anaesthesia, Tawam Hospital, Al Ain, Abu Dhabi, United Arab Emirates. Electronic address:

Article Synopsis
  • The review examines inadvertent cardiovascular medication errors during neuraxial procedures over the past 50 years, focusing on their prevalence, harm, and clinical consequences.
  • It highlights that these errors often involve drugs like digoxin and ephedrine, with many resulting in serious health issues, including permanent neurological deficits in some patients.
  • The analysis identifies key contributing factors to these errors, such as inadequate training for junior doctors and poor organizational practices, and recommends targeted safety strategies to prevent future incidents.
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Intrathecal administration of digoxin occurs very rarely. Some case reports of inadvertently administering it when performing spinal/epidural anesthesia were described. We report for the first time a case of a chemical meningitis and status epilepticus caused by accidental epidural administration of digoxin.

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