AI Article Synopsis
- Oral submucous fibrosis (OSMF) is a chronic condition often caused by areca nut chewing, and this study focuses on how serum trace elements (copper, iron, zinc, selenium) affect its progression and potential for cancer.
- The research involved 80 participants categorized into four groups based on their areca nut usage and OSMF status, with blood samples taken to analyze trace element levels.
- Results showed significant increases in serum copper and zinc in individuals with malignant-transformed OSMF compared to healthy controls, suggesting elevated copper may be a key marker for diagnosing OSMF's malignant transformation, warranting further investigation into copper chelation as a treatment option.
Article Abstract
Introduction: Oral submucous fibrosis (OSMF) is a chronic, potentially malignant disorder linked predominantly to areca nut chewing. This study investigates the role of serum trace elements (Cu, Fe, Zn, Se) in the progression and malignant transformation of OSMF.
Methodology: A community-based cross-sectional study involved 80 participants from the Government Dental College, Vijayawada, Krishna District, AP. Participants were divided into four groups: areca nut users without OSMF, areca nut users with OSMF, areca nut users with malignant-transformed OSMF, and healthy controls. Blood samples were analyzed for serum iron, copper, zinc, and selenium levels.
Results: Significant differences were found in serum copper (P=0.032) and zinc levels (P=0.006), with elevated levels observed in the malignant-transformed OSMF group compared to controls. No significant differences were observed in serum iron (P=0.542) and selenium levels (P=0.062) across the groups.
Conclusion: Elevated serum copper levels can serve as a reliable diagnostic marker for malignant transformation in OSMF. Future research should explore the potential therapeutic benefits of copper chelation in OSMF management.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344086 | PMC |
| http://dx.doi.org/10.7759/cureus.65314 | DOI Listing |
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