AI Article Synopsis
- This study introduces a method for treating pancreatic cancer with stereotactic body radiation therapy (SBRT) using a magnetic resonance-guided linear accelerator (MR-linac) that adapts daily and monitors motion in real-time while applying abdominal compression.
- The process involves a combination of MRI and CT simulations, including advanced imaging techniques to ensure accurate treatment planning and verification during radiation sessions.
- Results from 26 patients indicate that abdominal compression effectively reduces motion during treatment and yields clinical outcomes comparable to existing literature, allowing for more continuous treatment delivery compared to other techniques.
Article Abstract
Introduction: This work presents a method to treat stereotactic body radiation therapy (SBRT) for pancreatic cancer on a magnetic resonance-guided linear accelerator (MR-linac) using daily adaptation, real-time motion monitoring, and abdominal compression.
Methods: The motion management and treatment planning process involves a magnetic resonance imaging (MRI) simulation with cine and 3D images, a computed tomography (CT) simulation with a breath-hold CT and a 4DCT, pre-treatment verification and planning MRI, and intrafraction MRI cine images.
Results: The results from 26 patients were included in this work. Our motion management process results in consistent motion analysis on the CT simulation, MRI simulation, and each treatment fraction. The liver dome was found to be an overestimate of tumor superior/inferior (SI) motion for most patients. Adding compression reduced SI liver dome motion by 6.2 mm on average. Clinical outcomes are similar to those observed in the literature.
Conclusions: In this work, we demonstrate how pancreatic SBRT can be successfully treated on an MR-linac using abdominal compression. This allows for an increased duty cycle compared to gating and/or breath-hold techniques.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341468 | PMC |
| http://dx.doi.org/10.3389/fonc.2024.1441227 | DOI Listing |
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