, a distinctive Yi medicine, utilized the roots as an essential medicinal substance for trauma treatment of the "Yunnan Hong Yao". , however, cannot be cultivated artificially presently, and it has been described with a phenomenon of mixed utilization of roots and stems, impeding pharmaceutical quality control. In response to resource scarcity and standardization issues, the research comprehensively compares the material basis and efficacy of medicinal (roots) and non-medicinal (stems) parts by using chemical profiling and pharmacological methodologies. Chemical disparity between two parts was compared by TLC and HPLC. Analgesia and anti-inflammatory capabilities of both parts were comprehensively evaluated through acetic acid writhing test, hot plate test, and xylene-induced mouse ear swelling test. Additionally, all the extracts were evaluated for anti-inflammatory activities by monitoring regulation of the levels of TNF-, IL-1, IL-6, and IgE in ear tissue. Consequently, the findings of TLC and HPLC revealed substantial similarity in the material basis of the medicinal and non-medicinal parts of , and pharmacological activities of anti-inflammatory and analgesic between two parts were consistent. Different extracts remarkably reduced the levels of TNF-, IL-1, IL-6, and IgE, demonstrating no discernible differences. Collectively, the comprehensive exploitation indicated that the medicinal and non-medicinal parts of exhibited identical chemical profiling and bioactivities, providing a theoretical rationale and scientific evidence for using stems as a therapeutic part, thereby holding considerable potential for ameliorating the current status of its medicinal reserves.
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http://dx.doi.org/10.1016/j.heliyon.2024.e32408 | DOI Listing |
G protein-coupled receptors (GPCRs), the largest family of drug targets, can signal through 16 subtypes of Gα proteins. Biased compounds that selectively activate therapy-relevant pathways promise to be safer, more effective medications. The determinants of bias are poorly understood, however, and rationally-designed, G protein-subtype-selective compounds are lacking.
View Article and Find Full Text PDFNat Prod Res
December 2024
Department of Chemistry and Biochemistry, Faculty of Basic Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran.
The present study is centred on the analysis of the chemical compositions of essential oils (EOs) and volatile fractions extracted from the aerial parts of L. (APDSL) utilising traditional hydrodistillation (HD), solid phase microextraction (SPME), and a novel method known as innovative cigarette ignition (Incigig), all in combination with GC/MS. The results of this investigation reveal notable differences in both the types and relative percentages of the primary constituents; however, all identified profiles exhibit a significant presence of non-terpene hydrocarbons.
View Article and Find Full Text PDFArch Pharm (Weinheim)
January 2025
Laboratory of Pharmacognosy, Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
In this study, four depsides were isolated from Origanum dictamnus L. and Satureja pilosa Velen. medicinal plants and their structures were assessed by means of one-dimensional (1D)- and two-dimensional (2D)-nuclear magnetic resonance, high resolution mass spectrometry, and electronic circular dichroism analyses.
View Article and Find Full Text PDFEnviron Res
December 2024
Univ. Bordeaux, INSERM, Centre Bordeaux Population Health, Equipe Epicene, U1219, F-33000 Bordeaux, France; Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR S 1085, SFR ICAT, Poisoning Control Center - Prevention Federation, Angers, France; Epidemiology and Prevention, Donald and Barbare Zucket School of Medicine, Hofstra Univ Northwell Health, USA; CICEC.
Background: Numerous agents in the workplace are suspected of impairing fetal growth. To date, no epidemiological studies have specifically described the occupational exposome during pregnancy.
Objective: The objectives were to determine maternal occupational exposome profiles and study their associations with intrauterine growth characteristics measured by small for gestational age (SGA), birthweight (BW), and head circumference (HC).
Environ Pollut
December 2024
Institute of Quality Standard and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, and Key Laboratory of Agro-food Safety and Quality, Ministry of Agriculture and Rural Affairs, Beijing 100081, China. Electronic address:
The potential health risks of microplastics (MPs) and their combined exposure with heavy metals such as mercury (Hg) in aquatic environment are increasingly concerned recently. In this work, zebrafish embryos were exposed to different levels of polystyrene microplastics (PS-MPs, ∼0.1 μm) coupled with Hg(II) or/and MeHg at 20 μg/L, to investigate the tissue biodistribution and accumulation of PS-MPs and Hg species, and their interaction, as well as embryo toxicity, oxidative stress and metabolic profiles.
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