Introduction: We examined the relationship between sedentary behavior (SB), moderate-to-vigorous physical activity (MVPA), and white matter hyperintensity (WMH) volumes, a common magnetic resonance imaging (MRI) marker associated with risk of neurodegenerative disease in middle-aged to older adults.
Methods: We used data from the UK Biobank ( = 14,415; 45 to 81 years) that included accelerometer-derived measures of SB and MVPA, and WMH volumes from MRI.
Results: Both MVPA and SB were associated with WMH volumes (β= -0.03 [-0.04, -0.01], < 0.001; β= 0.02 [0.01, 0.03], = 0.007). There was a significant interaction between SB and MVPA on WMH volumes (β= -0.015 [-0.028, -0.001], = 0.03) where SB was positively associated with WMHs at low MVPA, and MVPA was negatively associated with WMHs at high SB.
Discussion: While this study cannot establish causality, the results highlight the potential importance of considering both MVPA and SB in strategies aimed at reducing the accumulation of WMH volumes in middle-aged to older adults.
Highlights: SB is associated with greater WMH volumes and MVPA is associated with lower WMH volumes.Relationships between SB and WMH are strongest at low levels of MVPA.Associations between MVPA and WMH are strongest at high levels of SB.Considering both SB and MVPA may be effective strategies for reducing WMHs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342350 | PMC |
| http://dx.doi.org/10.1002/dad2.70001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associations of blood pressure with white matter hyperintensities later in life; influence of short-term menopausal hormone therapy.
Menopause
January 2025
From the Department of Radiology, Mayo Clinic, Rochester, MN.
Objective: To assess the association of systolic and diastolic blood pressure (SBP and DBP) in recently menopausal women with white matter hyperintensity (WMH) volume later in life and determine whether short-term menopausal hormone therapy (mHT) modifies these associations.
Methods: Kronos Early Estrogen Prevention Study (KEEPS) was a multicenter, randomized, double-blinded, placebo-controlled 4-year mHT trial (oral conjugated equine estrogens or transdermal 17β-estradiol). KEEPS continuation was an observational follow-up of the participants 10 years after the end of mHT.
segcsvd: A Convolutional Neural Network-Based Tool for Quantifying White Matter Hyperintensities in Heterogeneous Patient Cohorts.
Hum Brain Mapp
December 2024
SEB Centre for Brain Resilience & Recovery, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada.
White matter hyperintensities (WMH) of presumed vascular origin are a magnetic resonance imaging (MRI)-based biomarker of cerebral small vessel disease (CSVD). WMH are associated with cognitive decline and increased risk of stroke and dementia, and are commonly observed in aging, vascular cognitive impairment, and neurodegenerative diseases. The reliable and rapid measurement of WMH in large-scale multisite clinical studies with heterogeneous patient populations remains challenging, where the diversity of imaging characteristics across studies adds additional complexity to this task.
View Article and Find Full Text PDFThe causal effects of gut microbiota on quantitative susceptibility mapping (QSM) and T2* imaging-derived phenotypes: insights from a Mendelian randomization study.
Quant Imaging Med Surg
December 2024
Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Background: Gut microbiota are associated with brain imaging-derived phenotypes (IDPs); however, the specific causal relationship between the gut microbiota and brain iron-related IDPs remains unclear. Thus, we sought to analyze the potential causal effects of gut microbiota on brain iron-related IDPs using Mendelian randomization (MR).
Methods: We obtained the data of 196 gut microbiota from a genome-wide association study (GWAS) from the MiBioGen database, as well as the data of 18 quantitative susceptibility mapping (QSM) IDPs and 10 T2* IDPs from the United Kingdom Biobank (UKB).
Cumulative anticholinergic exposure and white matter hyperintensity burden in community-dwelling older adults.
J Am Geriatr Soc
December 2024
School of Pharmacy, University of Washington, Seattle, Washington, USA.
Background: Anticholinergic exposure is associated with dementia risk; however, the mechanisms for this association remain unclear. The objective of this study was to examine the association between anticholinergic exposure and white matter hyperintensity (WMH) burden.
Methods: This was a retrospective analysis of data from the Adult Changes in Thought (ACT) study, a prospective cohort study among adults aged ≥65 years on dementia risk factors.
Sleep Disordered Breathing and Subsequent Neuroimaging Markers of Brain Health in Hispanic/Latino Adults.
Neurology
January 2025
From the Department of Neurology (A.R.R., C.A., S.K.), Miller School of Medicine, University of Miami, FL; University of California, San Diego (K.A.G., H.M.G.); Wayne State University (W.T.), Detroit, MI; Institute of Minority Health Research (M.D.), University of Illinois College of Medicine, Chicago; Department of Psychology (L.C.G., A.M.S., G.A.T.), San Diego State University, CA; Albert Einstein College of Medicine (C.I.I., R.B.L.), New York, NY; Department of Medicine (S.R.P.), University of Pittsburgh School of Medicine, PA; Brigham Women's Hospital (S.R.), Harvard School of Medicine, Boston, MA; Gillings School of Global Public Health (D.S.-A.), University of North Carolina, Chapel Hill; Department of Neurology and Rehabilitation (F.D.T.), University of Illinois College of Medicine, Chicago; and University of California, Davis (C.S.D.).
Article Synopsis
- Sleep disordered breathing (SDB) is a risk factor for stroke and Alzheimer’s disease, particularly among Hispanic/Latino adults, highlighting the need for research on its impact on brain health in this demographic.
- This study, based on the Hispanic Community Health Study, analyzed the association between SDB and brain MRI measures in a diverse group of Hispanic/Latino adults, using data from 2,667 participants with neuroimaging conducted about 10 years after initial sleep assessments.
- Results indicated that higher respiratory event index (REI) correlated with larger hippocampal volumes, while lower oxygen levels during sleep were related to expanded white matter hyperintensity (WMH) volumes, suggesting complex relationships between SDB, oxygen
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!