Objective: To investigate the 1 year mortality after hip fractures in super advanced age patients and summarize the death associated risk factors in order to provide basis for targeted intervention countermeasures.
Methods: The clinical data of 332 super advanced age patients with femoral neck or intertrochanteric fractures treated by hip replacement or intramedullary femoral nail fixation from January 2015 to January 2023 were retrospectively analyzed. There were 128 males and 204 females with the mean age of (92.2±2.5) years ranging from 90 to 103 years old. Among them, 92 cases died within 1 year after surgery. Correlation with the occurrence of death on age, gender, body mass index, fracture type, treatment method, timing of operation, preoperative hemoglobin and serum albumin level, operation time, combined medical diseases, pre-injury mobilityand American Society of Anesthesiology(ASA) classification were analyzed. The risk factors of death within 1 year after operation were screened by univariate analysis. The results were entered into the multivariate Logistic regression analysis, screening the high risk factors for 1 year mortality after hip fractures.
Results: The mortality of super advanced age patients with hip fracture within 1 year after surgery accounted for 27.7%(92/332). Univariate analysis showed high body mass index, long interval from injury to surgery, low preoperative serum albumin levels, inability to walk independently before injury, accompanied by heart failure, pulmonary infection, obstructive pulmonary disease, stroke, and a higher proportion of ASA grades Ⅲ-Ⅳ. Multivariate Logistic regression analysis showed preoperative serum albumin below 30g g·L[=2.973, 95%(2.461, 5.344), =0.039], inability to walk independently before injury [=3.519, 95%(2.224, 5.413), =0.018], heart function grade C-D[=4.213, 95%(2.952, 6.99), =0.021], pulmonary infection[=3.927, 95%(2.187, 7.731), =0.016] and ASA Ⅲ-Ⅳ[=5.124, 95%(3.092, 8.235), =0.032] were the independent risk factors for death within 1 year in super advanced age patients with hip fractures.
Conclusion: Preoperative serum albumin below 30g.L-1, poor preinjury activity, heart function grade C-D, pulmonary infection, and ASA grade Ⅲ-Ⅳ are independent risk factors for postoperative mortality in super advanced age patients with hip fractures.
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http://dx.doi.org/10.12200/j.issn.1003-0034.20231225 | DOI Listing |
Natl Sci Rev
January 2025
CAS Key Laboratory of Organic Solids, Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
In the face of advancements in microrobotics, intelligent control and precision medicine, artificial muscle actuation systems must meet demands for precise control, high stability, environmental adaptability and high integration miniaturization. Carbon materials, being lightweight, strong and highly conductive and flexible, show great potential for artificial muscles. Inspired by the butterfly's proboscis, we have developed a carbon-based artificial muscle, hydrogen-substituted graphdiyne muscle (HsGDY-M), fabricated efficiently using an emerging hydrogen-substituted graphdiyne (HsGDY) film with an asymmetrical surface structure.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Center of Super-Diamond and Advanced Films (COSDAF) and Department of Chemistry, City University of Hong Kong, Hong Kong SAR, 999077, P. R. China.
A new aggregation-induced emission (AIE) luminogen is obtained by dimerizing acridin-9(10H)-one (Ac), an aggregation-caused quenching (ACQ) effect monomer via an N─N bond and forming 9H,9'H-[10,10'-biacridine]-9,9'-dione (DiAc) with D symmetry. The quenching of DiAc in solution is ascribed to the enhanced basicity promoting hydrogen bonding and then a hydrogen abstraction (HA) reaction and/or an unallowed transition in frontier orbitals with the same symmetry facilitating intersystem crossing. It is found that emissive Ac is one product of the non-emissive DiAc solution in the HA reaction activated by UV irradiation.
View Article and Find Full Text PDFClin Genet
January 2025
Department of Human Genetics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Heterozygous pathogenic variants in MBD5 (MIM*611472) and CCM2 (MIM*607929) cause autosomal dominant intellectual developmental disorder 1 (MIM#156200) and cerebral cavernous malformations-2 (MIM#603284), respectively. Both conditions may present with seizures, epilepsy, and status epilepticus. However, super-refractory status epilepticus, defined as seizures lasting more than 24 h, has not been described in either condition.
View Article and Find Full Text PDFAnn Epidemiol
January 2025
School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Pietermaritzburg Campus, Pietermaritz.
Purpose: Epidemiologic studies are important in assessing risk factors of mortality. Machine learning (ML) is efficient in analyzing multidimensional data to unravel dependencies between risk factors and health outcomes.
Methods: Using a representative sample from the National Health and Nutrition Examination Survey data collected from 2009 to 2016 linked to the National Death Index public-use mortality data through December 31, 2019, we applied logistic, random forests, k-Nearest Neighbors, multivariate adaptive regression splines, support vector machines, extreme gradient boosting, and super learner ML algorithms to study risk factors of all-cause mortality.
Nat Commun
January 2025
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China.
The development of mechanically robust super-lubrication hydrogel materials with sustained lubricity at high contact pressures is challenging. In this work, inspired by the durable lubricity feature of the earthworm epidermis, a multilevel structural super-lubrication hydrogel (MS-SLH) system, the so-called lubricant self-pumping hydrogel, is developed. The MS-SLH system is manufactured by chemically dissociating a double network hydrogel to generate robust and wrinkled lubrication layer, and then laser etching was used to generate cylindrical texture pores as gland-like pockets for storing lubricants.
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