AI Article Synopsis
- Pogostemonis Herba, known for its use in traditional Chinese medicine, has potential to treat ulcerative colitis (UC) primarily through its main component, patchouli essential oil (PEO), although its pharmacological mechanisms are not fully understood.
- The study combined transcriptomic and network pharmacology methods, revealing that rectal administration of PEO in UC model mice significantly reduced UC symptoms by suppressing colonic inflammation and oxidative stress.
- PEO appears to work by modulating gut microbiota, inhibiting key inflammatory targets, and blocking the PI3K-AKT pathway, with specific bioactive components like pogostone identified for further potential therapeutic applications against UC.
Article Abstract
Ethnopharmacological Relevance: Pogostemonis Herba has long been used in traditional Chinese medicine to treat inflammatory disorders. Patchouli essential oil (PEO) is the primary component of Pogostemonis Herba, and it has been suggested to offer curative potential when applied to treat ulcerative colitis (UC). However, the pharmacological mechanisms of PEO for treating UC remain to be clarified.
Aim Of The Study: To elucidate the pharmacological mechanisms of PEO for treating UC.
Methods And Results: In the present study, transcriptomic and network pharmacology approaches were combined to clarify the mechanisms of PEO for treating UC. Our results reveal that rectal PEO administration in UC model mice significantly alleviated symptoms of UC. In addition, PEO effectively suppressed colonic inflammation and oxidative stress. Mechanistically, PEO can ameliorate UC mice by modulating gut microbiota, inhibiting inflammatory targets (OPTC, PTN, IFIT3, EGFR, and TLR4), and inhibiting the PI3K-AKT pathway. Next, the 11 potential bioactive components that play a role in PEO's anti-UC mechanism were identified, and the therapeutic efficacy of the pogostone (a bioactive component) in UC mice was partially validated.
Conclusion: This study highlights the mechanisms through which PEO can treat UC, providing a rigorous scientific foundation for future efforts to develop and apply PEO for treating UC.
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| http://dx.doi.org/10.1016/j.jep.2024.118737 | DOI Listing |
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