Food allergy yardstick: Where does omalizumab fit?

Ann Allergy Asthma Immunol

Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York.

Published: January 2025

AI Article Synopsis

  • Food allergy management has shifted from avoiding allergens to active treatments, highlighted by the approval of peanut immunotherapy in 2020 and the recent approval of omalizumab in 2024 for IgE-mediated food allergies.
  • Clinicians now have multiple treatment options and must understand the benefits, risks, and optimal use of these therapies to effectively manage patients.
  • A comprehensive review and expert opinion is provided to help clinicians incorporate omalizumab and other therapies into patient care through shared decision-making.

Article Abstract

Food allergy management has greatly evolved in the last several years, moving from passive approaches, such as strict food allergen avoidance, to more active treatments, including regulatory approval of the first specifically indicated immunotherapy product (for peanut) in 2020. In 2024, a second therapy, omalizumab, received regulatory approval for the treatment of 1 or more IgE-mediated food allergies, providing clinicians with multiple treatment options to offer patients and families. With this expanded armamentarium of food allergy treatment options, the practicing clinician requires detailed knowledge of benefits and risks of omalizumab, how omalizumab fits into the management landscape, and how to use shared decision-making to optimize therapy. This yardstick aims to provide the clinician with a review of data leading to omalizumab's food allergy indication and an evidence-based expert opinion approach regarding on how best to use this and other therapies available to optimize patient management.

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Source
http://dx.doi.org/10.1016/j.anai.2024.07.034DOI Listing

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