AI Article Synopsis
- Zebrafish are increasingly used in neuroscience research, necessitating effective data analysis tools, which have been enhanced by AI for better image and video tracking of their behavior.
- A new open-access AI platform was developed to analyze adult zebrafish movements after exposure to common psychoactive substances like nicotine, caffeine, and ethanol, demonstrating high accuracy in recognizing different drug effects.
- The study showcases the potential of tailored AI solutions to improve the understanding of CNS drug interactions in zebrafish, thus enhancing the effectiveness of drug research in a biomedical context.
Article Abstract
Background: Although zebrafish are increasingly utilized in biomedicine for CNS disease modelling and drug discovery, this generates big data necessitating objective, precise and reproducible analyses. The artificial intelligence (AI) applications have empowered automated image recognition and video-tracking to ensure more efficient behavioral testing.
New Method: Capitalizing on several AI tools that most recently became available, here we present a novel open-access AI-driven platform to analyze tracks of adult zebrafish collected from in vivo neuropharmacological experiments. For this, we trained the AI system to distinguish zebrafish behavioral patterns following systemic treatment with several well-studied psychoactive drugs - nicotine, caffeine and ethanol.
Results: Experiment 1 showed the ability of the AI system to distinguish nicotine and caffeine with 75 % and ethanol with 88 % probability and high (81 %) accuracy following a post-training exposure to these drugs. Experiment 2 further validated our system with additional, previously unexposed compounds (cholinergic arecoline and varenicline, and serotonergic fluoxetine), used as positive and negative controls, respectively.
Comparison With Existing Methods: The present study introduces a novel open-access AI-driven approach to analyze locomotor activity of adult zebrafish.
Conclusions: Taken together, these findings support the value of custom-made AI tools for unlocking full potential of zebrafish CNS drug research by monitoring, processing and interpreting the results of in vivo experiments.
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| http://dx.doi.org/10.1016/j.jneumeth.2024.110256 | DOI Listing |
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