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A noncanonical glycoprotein H complex enhances cytomegalovirus entry.
bioRxiv
October 2024
Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Human cytomegalovirus (HCMV) causes severe birth defects, lifelong health complications, and $4 billion in annual costs in the United States alone. A major challenge in vaccine design is the incomplete understanding of the diverse protein complexes the virus uses to infect cells. In , the gH/gL glycoprotein heterodimer is expected to be a basal element of virion cell entry machinery.
View Article and Find Full Text PDFPredicting cardiometabolic disease in medical students using FibroScan and 30-year Framingham risk scores.
Front Med (Lausanne)
September 2024
Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiovascular disease (CVD) are increasingly prominent health issues, especially among young adults, prompting a study on CVD risk and liver health in medical students.
- The research involved 138 healthy medical university students aged 18-30 who underwent physical assessments, surveys, and laboratory tests, leading to risk analysis for CVD and liver disease through Framingham risk scores and FibroScan measurements.
- Results indicated a low percentage of CVD risk among participants (1.5% to 17.6%) while 9.4% showed signs of liver fibrosis, with lifestyle factors like coffee and sugary drink consumption influencing liver health, as
Light-Driven Site-Selective Glycosylation of Native Carbohydrates.
Angew Chem Int Ed Engl
December 2024
LAQV REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
Carbohydrates constitute the largest source of biomass on Earth, but their synthetic modification is challenging due to their high content in oxygen functionalities. The site- and stereoselective modification of native sugars is a definite goal of glycochemistry research. Recent efforts to bypass the need for protecting groups, leveraging selective activation through photochemical mechanisms for site-selective C-C bond formation from native sugars, are likely to largely impact all glycochemistry-related areas.
View Article and Find Full Text PDFP2X receptors (P2XRs) are a family of ATP-gated ion channels comprising homomeric and heteromeric trimers of seven subunits (P2X - P2X ) that confer different rates of desensitization. The helical recoil model of P2XR desensitization proposes the stability of the cytoplasmic cap sets the rate of desensitization, but timing of its formation is unclear for slow-desensitizing P2XRs. We report cryo-EM structures of full-length, wild-type human P2X receptor in apo, antagonist-bound, and desensitized states.
View Article and Find Full Text PDFLowered GnT-I Activity Decreases Complex-Type N-Glycan Amounts and Results in an Aberrant Primary Motor Neuron Structure in the Spinal Cord.
J Dev Biol
August 2024
Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
The attachment of sugar to proteins and lipids is a basic modification needed for organismal survival, and perturbations in glycosylation cause severe developmental and neurological difficulties. Here, we investigated the neurological consequences of N-glycan populations in the spinal cord of Wt AB and mutant zebrafish. Mutant fish have reduced N-acetylglucosaminyltransferase-I (GnT-I) activity as remains intact.
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