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Ultra-Stiff yet Super-Elastic Graphene Aerogels by Topological Cellular Hierarchy.
Adv Mater
December 2024
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, 38 Zheda Road, Hangzhou, 310027, China.
Lightweight cellular materials with high stiffness and excellent recoverability are critically important in structural engineering applications, but the intrinsic conflict between these two properties presents a significant challenge. Here, a topological cellular hierarchy is presented, designed to fabricate ultra-stiff (>10 MPa modulus) yet super-elastic (>90% recoverable strain) graphene aerogels. This topological cellular hierarchy, composed of massive corrugated pores and nanowalls, is designed to carry high loads through predominantly reversible buckling within the honeycomb framework.
View Article and Find Full Text PDFOral administration of astaxanthin mitigates chronological skin aging in mice.
Biosci Biotechnol Biochem
December 2024
Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Intrinsic skin aging is a chronological decline in skin texture and function influenced largely by genetic factors. Aged skin exhibits morphological alterations, including wrinkling, dryness, and roughness, along with dysfunctional changes in the skin barrier. In this study, the in vivo anti-intrinsic aging efficacy of dietary astaxanthin extracted from Haematococcus pluvialis on the skin was evaluated using aged C57BL/6 J mice.
View Article and Find Full Text PDFInterferon-ε loss is elusive 9p21 link to immune-cold tumors, resistant to immune-checkpoint therapy and endogenous CXCL9/10 induction.
J Thorac Oncol
December 2024
Moores Cancer Center, University of California San Diego, La Jolla, CA 92037, USA; Department of Medicine, University of California San Diego, La Jolla, CA 92037, USA; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Introduction: Copy-number (CN) loss of chromosome 9p, or parts thereof, impair immune response and confer ICT resistance by direct elimination of immune-regulatory genes on this arm, notably IFNγ genes at 9p24.1, and type-I interferon (IFN-I) genes at 9p21.3.
View Article and Find Full Text PDFAssessing intrinsic capacity for person-centred HIV care: a cross-sectional study in ageing populations in Malaysia and Hong Kong.
J Int AIDS Soc
January 2025
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong.
Introduction: WHO's Integrated Care for Older People (ICOPE) proposes we measure the functional construct of intrinsic capacity (IC) to monitor and identify individuals with age-associated vulnerabilities. Assessments of IC may be useful to address the evolving, non-HV care needs of ageing people with HIV (PWH). However, to date, its utility within the context of HIV has not been assessed.
View Article and Find Full Text PDFBoosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change.
Neural Plast
December 2024
Department of Psychology, Sigmund Freud University, Milan, Italy.
The phenomenon of neural plasticity pertains to the intrinsic capacity of neurons to undergo structural and functional reconfiguration through learning and experiential interaction with the environment. These changes could manifest themselves not only as a consequence of various life experiences but also following therapeutic interventions, including the application of noninvasive brain stimulation (NIBS) and psychotherapy. As standalone therapies, both NIBS and psychotherapy have demonstrated their efficacy in the amelioration of psychiatric disorders' symptoms, with a certain variability in terms of effect sizes and duration.
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