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The cerebroplacental ratio: a useful marker but should it be a screening test?
Ultrasound Obstet Gynecol
January 2025
Department of Obstetrics and Gynecology, Hadassah Medical Center, Jerusalem, Israel.
Diagnostic value of combined maternal cardiac work and fetoplacental circulation parameters in detecting fetal intrauterine hypoxia in preeclamptic women.
Sci Rep
December 2024
Department of Ultrasound, Yantai Yuhuangding Hospital, Yantai, Shandong, China.
To investigate the correlation between fetoplacental circulation and maternal left ventricular myocardial work (MW) parameters in patients with preeclampsia (PE) and the prediction of fetal hypoxia. Seventy-eight PE patients (PE group) were assigned to intrauterine-hypoxia (27) and non-intrauterine-hypoxia (51) groups, and 45 healthy pregnant women were controls. The receiver operating characteristic (ROC) curve evaluated the diagnostic efficacy of each parameter for fetal intrauterine hypoxia.
View Article and Find Full Text PDFThe importance of the cerebro-placental ratio at term for predicting adverse perinatal outcomes in appropriate for gestational age fetuses.
J Perinat Med
December 2024
Department of Obstetrics, University Hospital Jena, Jena, Germany.
Objectives: This study investigates the relationship between the cerebro-placental ratio (CPR) measured at 40+0 weeks' gestation and perinatal outcomes to determine a CPR cut-off that may justify induction of labor at term in appropriately grown fetuses (AGA). Although CPR is used for monitoring growth-restricted fetuses, its role in guiding labor induction decisions for AGA pregnancies at term remains unclear.
Methods: A retrospective cohort study was conducted using data from 491 singleton pregnancies with intended vaginal deliveries between 2015 and 2021.
Maternal Serum SCUBE-1: A Novel Ischemic Marker in Preeclampsia.
J Pers Med
November 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
Article Synopsis
- SCUBE-1 is a new marker indicating ischemia and has been studied for its connection to uteroplacental blood flow in preeclampsia patients.
- In the study, 32 preeclamptic women showed significantly higher maternal serum SCUBE-1 levels compared to a control group of 32 healthy pregnancies, alongside elevated uterine artery pulsatility indexes.
- Although SCUBE-1 levels were higher in preeclampsia, there was no significant correlation with umbilical artery pulsatility index or cerebroplacental ratio, but a notable correlation was found with uterine artery pulsatility index.
Does Hypoxia Prompt Fetal Brain-Sparing in the Absence of Fetal Growth Restriction?
Physiol Res
November 2024
Department of Obstetrics and Gynecology, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.
The fetus develops normally in a hypoxic environment but exaggerated hypoxia late in pregnancy is a worrisome sign often observed in hypertensive disorders of pregnancy, placental insufficiency, or fetal growth restriction (FGR). Serial fetal biometry and the cerebroplacental ratio (CPR, calculated as the middle cerebral artery [MCA] / the umbilical artery [UmbA] pulsatility indices [PI]), are commonly used to indicate fetal "brain sparing" resulting from exaggerated fetal hypoxia. But unclear is the extent to which a low CPR indicates pathology or is a physiological response for maintaining cerebral blood flow.
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