Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S0140-6736(24)01507-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Screening and identification of multiple antibiotic- resistant genes containing Typhi from drinking water: A severe public health concern in Bangladesh.
Heliyon
November 2024
Laboratory of Microbial and Cancer Genomics, Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong, 4331, Bangladesh.
Article Synopsis
- * Out of 150 water samples, 8 isolates of Typhi were confirmed, revealing a troubling finding of antibiotic-resistant genes in all these isolates, which poses a threat to effective treatment.
- * Multidrug resistance (MDR) was confirmed in 87.5% of the isolates, indicating a widespread issue of antibiotic resistance, necessitating urgent action to prevent further transmission through contaminated water.
Typhoid & paratyphoid vaccine development in the laboratory: a review & in-country experience.
Indian J Med Res
December 2024
ICMR-National Institute of Occupational Health, Ahmedabad, Gujarat, India.
Enteric fever is caused by the infection of Gram-negative bacteria, Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi (S. Paratyphi) A, B and C, through contaminated food and water. The disease almost exclusively affects the populations living in low- and middle-income countries, with the World Health Organization Southeast Asian Region (WHO SEAR) having the highest endemicity.
View Article and Find Full Text PDFCLINICAL EFFICACY OF ORAL AZITHROMYCIN VERSUS OTHER ANTIMICROBIAL DRUGS IN THE TREATMENT OF TYPHOID PATIENTS ACROSS ALL AGE GROUPS: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS.
J Ayub Med Coll Abbottabad
December 2024
Federal Medical College, Islamabad-Pakistan.
Background: Typhoid is a major health concern. Drug-resistant cases of typhoid have given rise to new debates. Azithromycin has shown adequate results.
View Article and Find Full Text PDFImmunogenicity and cross-protective efficacy induced by delayed attenuated with regulated length of lipopolysaccharide in mice.
Gut Microbes
November 2024
College of Veterinary Medicine, Southwest University, Beibei, Chongqing, China.
Non-typhoidal (NTS) is a major global foodborne pathogen that poses a major public health concern worldwide, and no vaccines are available for protecting against infection of multiple serotypes, therefore, the development of vaccines to provide broad protection is valuable. In this work, we aimed to regulate lipopolysaccharide (LPS) synthesis of live for exposing conserved protein antigens on the outer membrane while maintaining smooth LPS patterns to keep their original ability to invade host cells for inducing cross-protection against infection of multiple serotypes. We generated a series of mutants defective in genes to affect the length of LPS.
View Article and Find Full Text PDFLoss of HIV candidate vaccine efficacy in male macaques by mucosal nanoparticle immunization rescued by V2-specific response.
Nat Commun
October 2024
Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Systemic vaccination of macaques with V1-deleted (ΔV1) envelope immunogens reduce the risk of SIV acquisition by approximately 60%, with protective roles played by V2-specific ADCC and envelope-specific mucosal IL-17NKp44 innate lymphoid cells (ILCs). We investigated whether increased mucosal responses to V2 benefit vaccine efficacy by delivering oral nanoparticles (NPs) that release V2-scaffolded on Typhoid Toxin B (TTB) to the large intestine. Strikingly, mucosal immunization of male macaques abrogated vaccine efficacy with control TTB or empty NPs, but vaccine efficacy of up to 47.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!