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Pott's puffy tumor with intracranial extension in a child with incontinentia pigmenti: case based review of the eponymous disease. | LitMetric

Pott's puffy tumor with intracranial extension in a child with incontinentia pigmenti: case based review of the eponymous disease.

Childs Nerv Syst

Division of Pediatric Neurosurgery, Children's Hospital of Eastern Ontario (CHEO), Rm 3359, 401 Smyth Rd, Ottawa, ON, K1H 8L1, Canada.

Published: November 2024

AI Article Synopsis

  • Pott's puffy tumor (PPT) is a rare infection of the frontal bone, posing serious neurological risks, and has been documented in cases involving immune dysfunction like Incontinentia pigmenti (IP).
  • A literature review found 12 cases of PPT linked to immune issues, with diabetes and iatrogenic immunosuppression as common causes; surgical intervention is the primary treatment.
  • PPT is increasingly recognized in patients with immune suppression, necessitating prompt and effective management to ensure better health outcomes.

Article Abstract

Background: Pott's puffy tumor (PPT) is an uncommon infection involving the frontal bone, first described by Sir Percival Pott more than 250 years ago. It can present with intracranial extension and serious neurological morbidity. Incontinentia pigmenti (IP) is a rare inherited genodermatosis that is lethal prenatally in males and manifests clinically in females. IP is associated with recurrent infections and immune dysfunction/suppression.

Methods: We report a case of Pott's puffy tumor presenting in a child with IP. We also performed a literature review of reported cases of PPT associated with immune dysfunction. We discuss the clinical presentation, diagnosis, and management of these lesions.

Results: We identified 12 cases of PPT associated with immune dysfunction/suppression. Diabetes was the most commonly identified cause followed by iatrogenic immunosuppression. Surgery is the standard treatment for managing PPT and the management of PPT with and without intracranial involvement, particularly in the context of underlying immune dysfunction/suppression, is discussed.

Conclusion: PPT remains a rare but not infrequent diagnosis, often requiring neurosurgical intervention. Immune dysfunction/suppression is an additional risk factor that may predispose to PPT. Early and aggressive management should be instituted for optimal outcome.

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Source
http://dx.doi.org/10.1007/s00381-024-06577-4DOI Listing

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