AI Article Synopsis
- Natural Killer (NK) cells are crucial components of the innate immune system that fight tumors by detecting and destroying abnormal cells in the body.
- They activate through various mechanisms, including the release of lytic granules, death receptor expression, and cytokine production to carry out their function.
- The review also discusses how NK cells interact with other immune cells in the tumor microenvironment, enhancing their anti-tumor response.
Article Abstract
Natural Killer (NK) cells are innate immune cells that play a pivotal role as first line defenders in the anti-tumor response. To prevent tumor development, NK cells are searching for abnormal cells within the body and appear to be key players in immunosurveillance. Upon recognition of abnormal cells, NK cells will become activated to destroy them. In order to fulfill their anti-tumoral function, they rely on the secretion of lytic granules, expression of death receptors and production of cytokines. Additionally, NK cells interact with other cells in the tumor microenvironment. In this review, we will first focus on NK cells' activation and cytotoxicity mechanisms as well as NK cells behavior during serial killing. Lastly, we will review NK cells' crosstalk with the other immune cells present in the tumor microenvironment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343846 | PMC |
| http://dx.doi.org/10.1038/s41419-024-06976-0 | DOI Listing |
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