Transferrin and ceruloplasmin have been measured by a solid-phase chemiluminescent method in seminal fluid and circulating blood of normal and vasectomized subjects (1 year after operation). This study has confirmed that approximately 80% of seminal transferrin comes from the testis, while seminal ceruloplasmin was not found different in the two groups. In patients affected by azoospermia due to seminiferous tubular damage (n = 15) in whom an obstruction was previously excluded, seminal transferrin was always below the normal range. On the contrary, seminal ceruloplasmin was always in the normal range, and circulating follicle-stimulating hormone was found above the normal range only in nine cases. No correlation was found between seminal transferrin and circulating follicle-stimulating hormone in such groups. In an unselected group of infertile patients with decreased sperm concentration and/or sperm motility, seminal transferrin was found correlated with the sperm count. These studies seem to suggest that seminal transferrin is a reliable index of seminiferous tubular function.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0015-0282(16)48388-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of Known Markers of Ferroptosis in Semen of Patients with Different Reproductive Pathologies and Fertile Men.
Cells
September 2024
Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
This study aims to investigate the role of ferroptosis, an iron-dependent form of regulated cell death, in male infertility. The motivation behind this research stems from the increasing recognition of oxidative stress and iron metabolism dysregulation as critical factors in male reproductive health. In this study, 28 infertile patients (grouped by the presence of urogenital infections or varicocele) and 19 fertile men were selected.
View Article and Find Full Text PDFSerum ferritin measurements differ according to the assay used: implications for iron therapy in restless legs syndrome.
J Clin Sleep Med
January 2025
Center for Sleep Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Study Objectives: Serum ferritin levels are used to determine the need for iron supplementation in patients with restless legs syndrome. The purpose of this study was to determine whether immunoassay measurement of serum ferritin yields varying levels according to different manufacturers' assays, with resultant variation in cutoff values.
Methods: We compared serum ferritin levels using 116 clinical samples assessed by the Beckman and Roche methods.
Source and level of dietary iron influence semen quality by affecting inflammation, oxidative stress and iron utilization levels in boars.
J Anim Sci Biotechnol
July 2024
Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Article Synopsis
- - The study investigated how different levels and types of iron supplements affect semen quality in 56 Topeka E line boars, focusing on various iron sources like Gly-Fe and MHA-Fe compared to a control group with ferrous sulfate.
- - Results indicated that lower dietary iron levels in certain groups did not negatively impact serum iron or hemoglobin levels, but significantly reduced inflammatory markers and lower sperm damage, suggesting improved semen quality.
- - Overall, while MHA-Fe seemed to enhance semen quality by decreasing abnormal sperm rates and inflammatory responses, Gly-Fe did not show significant benefits in improving semen quality in the boars.
The correlation between human seminal plasma sialoproteins and ejaculate parameters.
Int J Biol Macromol
May 2024
Laboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic; Department of Veterinary Sciences, Faculty of Agrobiology, Food and Natural Resources, University of Life Sciences Prague, Kamycka 129, 165 00 Prague 6, Czech Republic. Electronic address:
Sialic acids are negatively charged carbohydrates that are components of saccharide chains covalently linked to macromolecules. Sialylated glycoproteins are important for most biological processes, including reproduction, where they are associated with spermatogenesis, sperm motility, immune responses, and fertilization. Changes in the glycoprotein profile or sialylation in glycoproteins are likely to affect the quality of ejaculate.
View Article and Find Full Text PDFExploring the Specific Role of Iron Center in the Catalytic Activity of Human Serum Transferrin: CTAB-Induced Conformational Changes and Sequestration by Mixed Micelles.
Langmuir
March 2024
Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhopal 462 066, Madhya Pradesh, India.
Conformational changes play a seminal role in modulating the activity of proteins. This concept becomes all the more relevant in the context of metalloproteins, owing to the formation of specific conformation(s) induced by internal perturbations (like a change in pH, ligand binding, or receptor binding), which may carry out the binding and release of the metal ion/ions from the metal binding center of the protein. Herein, we investigated the conformational changes of an iron-binding protein, monoferric human serum transferrin (Fe-hTF), using several spectroscopic approaches.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!