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http://dx.doi.org/10.1097/NNE.0000000000001727 | DOI Listing |
Alzheimers Dement
December 2024
UIPS, CHANDIGARH, Punjab, India.
Background: Alzheimer's disease is a brain disorder that causes neurodegeneration and is linked with insulin resistance at molecular, clinical, and demographic levels. Defective insulin signaling promotes Aβ aggregation and accelerates Aβ formation in the brain leading to Type III diabetes.
Objective: The objective of this research project is to demonstrate a linkage if any between the risk of developing Alzheimer's disease and insulin resistance.
Up to date, there are no precise reports of the prevalence of dementia with Lewy bodies (DLB) in Latin America. This can be explained by the lack of research studies and general little awareness about the disease. Notably, collaborative clinical studies are lacking, and DLB patients remain underrepresented despite their significant morbidity.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Cognitive Impairment Diagnosis and Dementia Prevention Unit, Peruvian Institute of Neurosciences, Lima, Lima, Peru.
Background: The prevalence of dementia in Low and Middle-Income Countries (LMICs), particularly in Latin America and the Caribbean (LAC), is projected to triple by 2050. The Montreal Cognitive Assessment (MoCA) is widely used for cognitive evaluation, but its uniform application in LAC is questionable, especially due to cultural and linguistic diversity of the Spanish-speaking LAC countries.
Method: A systematic literature search was conducted across seven databases, supplemented by a comprehensive review using Google Scholar to identify relevant grey literature.
Alzheimers Dement
December 2024
College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Background: The emergence of dementia as a global health challenge necessitates an exploration of its unique epidemiological patterns and risk factors in Sub-Saharan Africa (SSA). Amid a growing elderly population, SSA presents an intriguing paradox of lower-than-expected dementia prevalence, prompting a comprehensive review of epidemiological nuances, lifestyle risk factors, cultural influences, and protective factors. This study critically assessed the current state of dementia research in SSA, aiming to inform tailored interventions and policies.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Johns Hopkins Global Neurology, University Teaching Hospital, Lusaka, Lusaka, Zambia.
Background: Globally, 47.5 million people were living with dementia in 2015. This figure is expected to reach 75.
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