AI Article Synopsis
- Spatial transcriptomic (ST) profiling allows researchers to map gene expression in skin cells while keeping track of their specific locations, enhancing our understanding of skin biology in both healthy and diseased states.
- The paper reviews various ST methods and their relevance to dermatology, showcasing the technology's ability to analyze many genes at once.
- The potential benefits of ST in dermatology are illustrated through examples related to skin aging, cancer development, and psoriasis, suggesting significant advancements in our knowledge of skin health and disease.
Article Abstract
Spatial transcriptomic (ST) profiling is the mapping of gene expression within cell populations with preservation of positional context and represents an exciting new approach to develop our understanding of local and regional influences upon skin biology in health and disease. With the ability to probe from a few hundred transcripts to the entire transcriptome, multiple ST approaches are now widely available. In this paper, we review the ST field and discuss its application to dermatology. Its potential to advance our understanding of skin biology in health and disease is highlighted through the illustrative examples of 3 research areas: cutaneous aging, tumorigenesis, and psoriasis.
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| http://dx.doi.org/10.1016/j.jid.2024.07.006 | DOI Listing |
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