The decarboxylation of naturally abundant amino acids, followed by subsequent inter- or intramolecular reaction cascades, enables the rapid synthesis of a variety of diverse and high-value amine derivatives. Previous methods have relied heavily on transition metals, involved tedious procedures, or required harsh conditions. Herein, we present a novel reaction cascade for the decarboxylation and nucleophilic functionalization of α-amino acids. This method is characterized by being transition-metal-free, convenient to operate, environmentally friendly and having mild conditions.
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| http://dx.doi.org/10.1021/acs.orglett.4c02589 | DOI Listing |
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