AI Article Synopsis

  • Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic condition affecting the gastrointestinal tract, and recent advancements in treatment have come from biologic therapies targeting interleukins (ILs).
  • The review highlights the roles of key ILs in IBD and evaluates the effectiveness and positioning of specific anti-IL therapies, notably ustekinumab, risankizumab, and mirikizumab, in achieving remission for patients.
  • While these therapies generally have favorable safety profiles, the review notes that long-term safety data for newer treatments is still limited, suggesting that anti-IL therapies could serve as effective first- or second-line options for many patients with moderate to severe I

Article Abstract

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disease of the gastrointestinal tract. The introduction of biologics, particularly anti-interleukin (IL) agents, has revolutionized IBD treatment. This review summarizes the role of ILs in IBD pathophysiology and describes the efficacy and positioning of anti-IL therapies. We discuss the functions of key ILs in IBD and their potential as therapeutic targets. The review then discusses anti-IL therapies, focusing primarily on ustekinumab (anti-IL-12/23), risankizumab (anti-IL-23), and mirikizumab (anti-IL-23). Clinical trial data demonstrate their efficacy in inducing and maintaining remission in Crohn's disease and ulcerative colitis. The safety profiles of these agents are generally favorable. However, long-term safety data for newer agents are still limited. The review also briefly discusses emerging therapies such as guselkumab and brazikumab. Network meta-analyses suggest that anti-IL therapies perform well compared to other biological agents. These agents may be considered first- or second-line therapies for many patients, especially those with comorbidities or safety concerns. Anti-IL therapies represent a significant advancement in IBD treatment, offering effective and relatively safe options for patients with moderate to severe disease.

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Source
http://dx.doi.org/10.4166/kjg.2024.076DOI Listing

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