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Understanding premenstrual exacerbation: navigating the intersection of the menstrual cycle and psychiatric illnesses. | LitMetric

AI Article Synopsis

Article Abstract

Premenstrual exacerbation of an existing psychiatric disorder refers to the worsening of symptoms inherent to the condition during the premenstrual phase. Research consistently indicates that hormonal fluctuations during the menstrual cycle present a unique period of vulnerability for the onset or exacerbation of psychiatric symptoms, impacting diagnosis, risk assessment, and treatment. This review sought to elucidate the phenomenon of premenstrual exacerbation and its impact across a spectrum of psychiatric illnesses, including mood, anxiety, psychotic, obsessive-compulsive, personality, and trauma-related disorders. Despite the expanded research in recent years on premenstrual dysphoric disorder and premenstrual syndrome, premenstrual exacerbation remains underexplored and poorly defined. This review offers significant contributions to the diagnosis and management of psychiatric conditions, advocating for heightened awareness and novel treatment approaches in the context of premenstrual exacerbation.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338788PMC
http://dx.doi.org/10.3389/fpsyt.2024.1410813DOI Listing

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Premenstrual Symptoms Risk Factors Among Newly Graduated Nurses in Shift Work: A Prospective Longitudinal Study.

Asian Nurs Res (Korean Soc Nurs Sci)

December 2024

College of Nursing, Research Institute of Nursing Science, Jeonbuk National University, Republic of Korea; Biomedical Research Institute, Jeonbuk National University Hospital, Republic of Korea. Electronic address:

Purpose: The premenstrual symptoms (PMSs) are a common health issue affecting women of reproductive age and are associated with various physiological, psychological, and situational factors. Newly graduated nurses, when suddenly exposed to excessive workloads and shift work, may experience disturbances such as sleep disorders, fatigue, depression, and stress. These factors are related to PMS, and their occurrence varies.

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Article Synopsis
  • Premenstrual Disorders (PMDs), including PMS and PMDD, significantly affect women, and childhood trauma may increase the risk of experiencing these disorders and premenstrual exacerbation (PME).
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Article Synopsis
  • The study aimed to explore the link between childhood traumas and the occurrence of premenstrual syndrome (PMS) in women aged 18-49, revealing that childhood traumas could increase PMS symptoms.
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Purpose Of Review: We reviewed a wide body of emerging research highlighting the possibility for premenstrual exacerbations of mood symptoms in polycystic ovary syndrome (PCOS).

Recent Findings: Neuroendocrine dysregulation, sensitivity to ovarian hormone fluctuations as well as higher levels and types of adverse childhood experiences and demographic factors are emerging factors explaining high rates of psychiatric disorders in PCOS. Ovulatory dysfunction, common in PCOS, significantly interferes with one's identity and quality of life.

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Purpose Of Review: To explore the relationship between early life trauma, hormonal sensitivity, and psychiatric disorders across female-reproductive life events, with a focus on the neurobiological mechanisms.

Recent Findings: Childhood trauma significantly increases the risk of subsequent mood disorders during periods of intense hormonal fluctuation such as premenstrual, pregnancy, postpartum, and perimenopause. Neurobiological changes resulting from early trauma influence emotion regulation, which emerges as a key predisposing, exacerbating, and perpetuating factor to hormonal sensitivity and subsequent psychiatric symptoms.

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