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Polarization optical coherence tomography optoretinography: verifying light-induced photoreceptor outer segment shrinkage and subretinal space expansion.
Neurophotonics
January 2025
University of Illinois Chicago, Department of Biomedical Engineering, Chicago, Illinois, United States.
Significance: Stimulus-evoked intrinsic optical signal (IOS) changes in retinal photoreceptors are critical for functional optoretinography (ORG). Optical coherence tomography (OCT), with its depth-resolved imaging capability, has been actively explored for IOS imaging of retinal photoreceptors. However, recent OCT studies have reported conflicting results regarding light-induced changes in the photoreceptor outer segments (OSs), with both elongation and shrinkage being observed.
View Article and Find Full Text PDFResearch Best Practices for Eye Stroke Vision Rehabilitation: A Qualitative Study.
Curr Eye Res
January 2025
Department of Ophthalmology, Duke University, Durham, NC, USA.
Purpose: Central retinal artery occlusion, also known as an eye stroke, results in visual impairment and functional challenges. Our study objectives were to identify meaningful measures and factors that indicate or enable successful recovery after eye stroke and to determine optimal processes to support research, including exploring barriers and facilitators to successful research participation.
Methods: We used qualitative methods including the 5Ts Framework (target population identification, team composition, time considerations, tips to accommodate older adults, tools for inclusive enrollment of older adults) to provide a guide to the development of the semi-structured interviews and to help facilitate the research process such as the set-up of interviews.
Nanoscale visualization of crack tips inside molten corium-concrete interaction debris using 3D-FIB-SEM with multiphase positional misalignment correction.
Microscopy (Oxf)
January 2025
Faculty of Engineering, Kyushu University, Fukuoka 819-0395, Japan.
Characterizing molten corium-concrete interaction (MCCI) fuel debris in Fukushima reactors is essential to develop efficient methods for its removal. To enhance the accuracy of microscopic observation and focused ion beam (FIB) microsampling of MCCI fuel debris, we developed a three-dimentional FIB scanning electron microscopy (SEM) technique with a multiphase positional misalignment (MPPM) correction method. This system automatically aligns voxel positions, corrects contrast, and removes artifacts from a series of over 500 SEM images.
View Article and Find Full Text PDFBuilding an Easy-to-Assemble, Low-Cost Phonomicrosurgery Dissection Model: A Technical Report From the University of Cartagena.
Cureus
December 2024
Otolaryngology, Universidad De Cartagena, Cartagena, COL.
In otolaryngology, training often involves simulation in animal specimens, human cadavers, and artificial models to facilitate learning surgical procedures, reducing the time needed to acquire essential skills. Simulated training has become integral to medical education, particularly in microsurgical techniques, such as microlaryngeal surgery. These procedures, also known as phonomicrosurgery, are performed on the vocal folds using microscopic visualization and precision instruments with long shafts and millimetric tips.
View Article and Find Full Text PDFCRMP/UNC-33 maintains neuronal microtubule arrays by promoting individual microtubule rescue.
Curr Biol
January 2025
Department of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address:
Microtubules (MTs) are intrinsically dynamic polymers. In neurons, staggered individual microtubules form stable, polarized acentrosomal MT arrays spanning the axon and dendrite to support long-distance intracellular transport. How the stability and polarity of these arrays are maintained when individual MTs remain highly dynamic is still an open question.
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