Visible-light-promoted selenylation/cyclization of -(1-alkynyl) benzoates to access seleno-substituted isocoumarins.

Org Biomol Chem

Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, Key Laboratory of Medical Biotechnology and Translational Medicine, School of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, China..

Published: September 2024

A simple and efficient method to access 4-selenyl-isocoumarin derivatives through visible-light-promoted selenylation/cyclization of -(1-alkynyl) benzoates has been developed. This transformation is performed under mild conditions and has the advantages of functional group tolerance and broad substrate scope.

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Source
http://dx.doi.org/10.1039/d4ob01010hDOI Listing

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