AI Article Synopsis
- The study explores how specific microstructural features on bone implants can influence biological response and aid in bone growth (osteogenesis).
- It demonstrates that a dual-scale hierarchical structure enhances the attachment and proliferation of osteoblasts by optimizing mechanical forces, as well as upregulating important receptors for cell growth.
- Additionally, the research shows that this structure facilitates effective bone formation by activating key signaling pathways (like TGF-β and cAMP) and promoting calcium deposition for better implant stability.
Article Abstract
The structural characteristics at the interface of bone implants can guide biological regulation. In this study, a dual-scale hierarchical microstructure is proposed and customized using hybrid machining to achieve temporal dependency osteogenic regulation. It is observed that osteoblasts induced by dual-scale hierarchical structure exhibit adequate protrusion development and rapid cell attachment through the modulation of mechanical forces in the cell growth environment, and further promot the upregulation of the cell membrane receptor PDGFR-α, which is related to cell proliferation. Afterward, transcriptomic analysis reveals that during the differentiation stage, the DSH structure regulates cellular signaling cascades primarily through integrin adhesion mechanisms and then accelerates osteogenic differentiation by activating the TGF-β pathway and cAMP signaling pathway. Furthermore, the calcium nodules are preferentially deposited within the lower honeycomb-like channels, thereby endowing the proposed dual-scale hierarchical structure with the potential to induce oriented deposition and improve the long-term stability of the implant.
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| http://dx.doi.org/10.1002/adhm.202402369 | DOI Listing |
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