AI Article Synopsis
- Peripheral vascular interventions (PVIs) are less painful, require simpler anesthesia, and have shorter recovery times than traditional surgery, but they involve X-ray fluoroscopy, which can harm both patients and doctors.
- The study introduces a quantum dot (QD)-based magnetic guidewire system that allows for X-ray-free imaging using shortwave infrared (SWIR) technology, enhancing safety during procedures.
- The QD guidewire is made of a flexible silicone tube with QDs for bioimaging and includes a permanent magnet for precise navigation, showing promise for future use in clinical settings due to its biocompatibility and resistance to degradation.
Article Abstract
Peripheral vascular interventions (PVIs) offer several benefits to patients with lower extremity arterial diseases, including reduced pain, simpler anesthesia, and shorter recovery time, compared to open surgery. However, to monitor the endovascular tools inside the body, PVIs are conducted under X-ray fluoroscopy, which poses serious long-term health risks to physicians and patients. Shortwave infrared (SWIR) imaging of quantum dots (QDs) has shown great potential in bioimaging due to the non-ionizing penetration of SWIR light through tissues. In this paper, a QD-based magnetic guidewire and its system is introduced that allows X-ray-free detection under SWIR imaging and precise steering via magnetic manipulation. The QD magnetic guidewire contains a flexible silicone tube encapsulating a QD polydimethylsiloxane (PDMS) composite, where HgCdSe/HgS/CdS/CdZnS/ZnS/SiO core/multi-shell QDs are dispersed in the PDMS matrix for SWIR imaging upon near-infrared excitation, as well as a permanent magnet for magnetic steering. The SWIR penetration of the QD magnetic guidewire is investigated within an artificial tissue model (1% Intralipid) and explore the potential for non-fluoroscopic PVIs within a vascular phantom model. The QD magnetic guidewire is biocompatible in its entirety, with excellent resistance to photobleaching and chemical alteration, which is a promising sign for its future clinical implementation.
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| http://dx.doi.org/10.1002/smll.202404251 | DOI Listing |
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