AI Article Synopsis
- Development of a new copper(II) complex using a natural D-glucose-derived ligand aims to create eco-friendly catalytic systems.
- The structure of the synthesized complex was confirmed using advanced methods like single-crystal X-ray diffraction and Hirshfeld surface analysis.
- This complex effectively catalyzes a coupling reaction for producing propargylamines with high enantioselectivity and yield, and it can be reused without losing effectiveness.
Article Abstract
Development of catalytic systems using nontoxic natural precursors is the need of the era, and along this line, we have synthesized a new D-glucose derived ligand (4,6-O-ethylidene-N-(2-hydroxy-4-(octyloxy)benzylidene)-β-D-glucopyranosylamine) and its dinuclear copper(II) complex. The molecular structure of the complex has been established by single-crystal X-ray diffraction studies and detailed noncovalent intermolecular interactions present in it have been explored by Hirshfeld surface analysis. Further, the complex has been used as a catalyst in the enantioselective (87-99 % ee) synthesis of propargylamines in good to excellent yield (82-95 %) via aldehyde-amines-alkynes (A) coupling reaction under solvent-free condition. The formation of aminal intermediate during the reaction has been confirmed by H-NMR and single-crystal X-ray diffraction studies. The catalytic system is reusable without any appreciable loss in the enantioselectivity or product yield.
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| http://dx.doi.org/10.1002/cplu.202400381 | DOI Listing |
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