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Application and interpretation of core elements of the 2015 NMOSD diagnostic criteria in routine clinical practice.
Front Immunol
December 2024
Department of Neurology, University of Virginia, Charlottesville, VA, United States.
Background: We evaluated comprehension and application of the 2015 neuromyelitis optica spectrum disorder (NMOSD) criteria core elements by neurologists in Latin America (LATAM) who routinely diagnose and care for NMOSD patients by (i) identifying typical/suggestive NMOSD syndromes, (ii) detecting typical MRI NMOSD lesions and meeting MRI dissemination in space (DIS) criteria, and (iii) evaluating historical symptoms suggestive of NMOSD.
Methods: We conducted an anonymous, voluntary, self-administered web- and case-based survey cross-sectional study from October 2023 to January 2024 of neurologists identified through the LACTRIMS database. Questions were presented first through iterative clinical cases or imaging, followed by questions directly evaluating comprehension of definitions.
Osteoimmunology in bone malignancies: a symphony with evil.
J Natl Cancer Cent
December 2024
Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology, Life Sciences Institute, and Department of Orthopaedic Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Bone marrow is pivotal for normal hematopoiesis and immune responses, yet it is often compromised by malignancies. The bone microenvironment (BME), composed of bone and immune cells, maintains skeletal integrity and blood production. The emergence of primary or metastatic tumors in the skeletal system results in severe complications and contributes significantly to cancer-related mortality.
View Article and Find Full Text PDFLASP to the Future of Atomic Simulation: Intelligence and Automation.
Precis Chem
December 2024
Collaborative Innovation Center of Chemistry for Energy Material, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Key Laboratory of Computational Physical Science, Department of Chemistry, Fudan University, Shanghai 200433, China.
Atomic simulations aim to understand and predict complex physical phenomena, the success of which relies largely on the accuracy of the potential energy surface description and the efficiency to capture important rare events. LASP software (large-scale atomic simulation with a Neural Network Potential), released in 2018, incorporates the key ingredients to fulfill the ultimate goal of atomic simulations by combining advanced neural network potentials with efficient global optimization methods. This review introduces the recent development of the software along two main streams, namely, higher intelligence and more automation, to solve complex material and reaction problems.
View Article and Find Full Text PDFEstimating baselines of Raman spectra based on transformer and manually annotated data.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Department of Agricultural Technology, Center for Precision Agriculture, Norwegian Institute of Bioeconomy Research (NIBIO), Nylinna 226 2849, Kapp, Norway.
Raman spectroscopy is a powerful and non-invasive analytical method for determining the chemical composition and molecular structure of a wide range of materials, including complex biological tissues. However, the captured signals typically suffer from interferences manifested as noise and baseline, which need to be removed for successful data analysis. Effective baseline correction is critical in quantitative analysis, as it may impact peak signature derivation.
View Article and Find Full Text PDFInactivation of the SLC25A1 gene during embryogenesis induces a unique senescence program controlled by p53.
Cell Death Differ
December 2024
Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, D.C., USA.
Germline inactivating mutations of the SLC25A1 gene contribute to various human disorders, including Velocardiofacial (VCFS), DiGeorge (DGS) syndromes and combined D/L-2-hydroxyglutaric aciduria (D/L-2HGA), a severe systemic disease characterized by the accumulation of 2-hydroxyglutaric acid (2HG). The mechanisms by which SLC25A1 loss leads to these syndromes remain largely unclear. Here, we describe a mouse model of SLC25A1 deficiency that mimics human VCFS/DGS and D/L-2HGA.
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