AI Article Synopsis
- Cutaneous leishmaniasis in Sri Lanka is unusual, as it is typically caused by Leishmania donovani, which is mainly associated with visceral disease.
- Genome analysis of clinical isolates from Sri Lanka revealed that both L. donovani and L. tropica are present, with some L. tropica strains linked to older Indian isolates rather than recent hybrids.
- The findings suggest that L. donovani is not the sole cause of cutaneous leishmaniasis in Sri Lanka, pointing to potential interspecies hybrids contributing to the disease.
Article Abstract
Cutaneous leishmaniasis is atypical in Sri Lanka because Leishmania donovani, which typically causes visceral disease, is the causative agent. The origins of recently described hybrids between L. donovani and other Leishmania spp. usually responsible for cutaneous leishmaniasis remain unknown. Other endemic dermotropic Leishmania spp. have not been reported in Sri Lanka. Genome analysis of 27 clinical isolates from Sri Lanka and 32 Old World Leishmania spp. strains found 8 patient isolates clustered with L. tropica and 19 with L. donovani. The L. tropica isolates from Sri Lanka shared markers with strain LtK26 reported decades ago in India, indicating they were not products of recent interspecies hybridization. Because L. tropica was isolated from patients with leishmaniasis in Sri Lanka, our findings indicate L. donovani is not the only cause of cutaneous leishmaniasis in Sri Lanka and potentially explains a haplotype that led to interspecies dermotropic L. donovani hybrids.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11347009 | PMC |
| http://dx.doi.org/10.3201/eid3009.231238 | DOI Listing |
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