AI Article Synopsis
- Measles cases in individuals with secondary vaccination failure (SVF) are less infectious compared to unvaccinated individuals, according to a systematic review.
- The review analyzed 14 studies involving over 3,030 people exposed to measles from SVF cases, revealing a low secondary attack rate of 0%-6.25%.
- Only 10.09% of SVF cases transmitted the virus, suggesting that in outbreak situations, public health efforts should focus more on unvaccinated individuals than those with SVF.
Article Abstract
Measles in persons with secondary vaccination failure (SVF) may be less infectious than cases in unvaccinated persons. Our systematic review aimed to assess transmission risk for measles after SVF. We searched PubMed, Embase, and Web of Science databases from their inception dates. Inclusion criteria were articles describing persons who were exposed to measles-infected persons who had experienced SVF. Across the included 14 studies, >3,030 persons were exposed to measles virus from SVF cases, of whom 180 were susceptible, indicating secondary attack rates of 0%-6.25%. We identified 109 cases of SVF from the studies; 10.09% (n = 11) of case-patients transmitted the virus, resulting in 23 further cases and yielding an effective reproduction number of 0.063 (95% CI 0.0-0.5). These findings suggest a remarkably low attack rate for SVF measles cases, suggesting that, In outbreak situations, public health management of unvaccinated persons could be prioritized over persons with SVF.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346981 | PMC |
| http://dx.doi.org/10.3201/eid3009.240150 | DOI Listing |
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