Rationally reprogramming single-cell aging trajectories and lifespan through dynamic modulation of environmental inputs.

Cell Syst

Department of Basic Medical Sciences, School of Medicine, Koç University, Sarıyer, İstanbul, Türkiye; Koç University Research Center for Translational Medicine, Sarıyer, İstanbul, Türkiye. Electronic address:

Published: August 2024

How do variations in nutrient levels influence cellular lifespan? A dynamical systems model of a core circuit involved in yeast aging suggests principles underlying lifespan extension observed at static and alternating glucose levels that are reminiscent of intermittent fasting regimens.

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http://dx.doi.org/10.1016/j.cels.2024.07.008DOI Listing

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